Evidence map›Paper›PMID 38497739›Full record

ReviewJournal of neurotrauma2024

Visual Impairment in Pre-Clinical Models of Mild Traumatic Brain Injury.

Gabriella Orbach, Eva J Melendes, Kaitlyn Warren, Jianhua Qiu, William P Meehan, Rebekah Mannix, Fernanda Guilhaume-Correa

Open access · greenAbstract readReview
In one paragraph

Review in Journal of neurotrauma, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Gabriella OrbachTufts University School of Medicine, Boston, Massachusetts, USA.
Eva J MelendesDivision of Emergency Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Kaitlyn WarrenDivision of Emergency Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Jianhua QiuDivision of Emergency Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
William P MeehanDivision of Sports Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Rebekah MannixDivision of Emergency Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Fernanda Guilhaume-CorreaDivision of Emergency Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Boston Children's Hospital · USTufts University · US

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
RESEARCH TRAINING IN PEDIATRIC EMERGENCY MEDICINET32HD040128 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI Kenneth D. Mandl · 2001 to 2026
$5.0M
NICHD NIH HHS P50 HD105351NICHD NIH HHS T32 HD040128
6 · The paper itself

Abstract

Impairment in visual function is common after traumatic brain injury (TBI) in the clinical setting, a phenomenon that translates to pre-clinical animal models as well. In Morris et al. (2021), we reported histological changes following weight-drop-induced TBI in a rodent model including retinal ganglion cell (RGC) loss, decreased electroretinogram (ERG) evoked potential, optic nerve diameter reduction, induced inflammation and gliosis, and loss of myelin accompanied by markedly impaired visual acuity. In this review, we will describe several pre-clinical TBI models that result in injuries to the visual system, indicating that visual function may be impaired following brain injury induced by a number of different injury modalities. This underscores the importance of understanding the role of the visual system and the potential detrimental sequelae to this sensory modality post-TBI. Given that most commonly employed behavioral tests such as the Elevated Plus Maze and Morris Water Maze rely on an intact visual system, interpretation of functional deficits in diffuse models may be confounded by off- target effects on the visual system.

Indexed as

Disease Models, AnimalVision DisordersAnimalsBrain Concussionbehavior testin vivo studiesmodels of injurytraumatic brain injuryvisual system

Identifiers

PMID38497739
PMCPMC11386989
OpenAlexW4392911504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.