Evidence map›Paper›PMID 38497715›Full record

ArticleMicrobiology spectrum2024

Combining fecal microbiome and metabolomics reveals diagnostic biomarkers for esophageal squamous cell carcinoma.

Mingjun Gao, Jun Wu, Siding Zhou, Yong Chen, Mengmeng Wang, Wenbo He, Lei Jiang, Yusheng Shu, Xiaolin Wang

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. The role of theFrontiers in microbiology · 2026
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  12. Shotgun Metagenomics RevealsGastro hep advances · 2025
    Review
  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mingjun GaoDalian Medical University, Dalian, China.
Jun WuClinical Medical College of Yangzhou University, Yangzhou, China.
Siding ZhouClinical Medical College of Yangzhou University, Yangzhou, China.
Yong ChenDalian Medical University, Dalian, China.
Mengmeng WangDalian Medical University, Dalian, China.
Wenbo HeClinical Medical College of Yangzhou University, Yangzhou, China.
Lei JiangDepartment of Thoracic Surgery, Northern Jiangsu People's Hospital, Yangzhou, China.
Yusheng ShuDepartment of Thoracic Surgery, Northern Jiangsu People's Hospital, Yangzhou, China.ORCID 0000-0002-8423-0422
Xiaolin WangDepartment of Thoracic Surgery, Northern Jiangsu People's Hospital, Yangzhou, China.ORCID 0000-0001-5029-982X
Dalian Medical University · CNNorthern Jiangsu People's Hospital · CNYangzhou University · CN

Funding

Jiangsu Provincial Health Commission Elderly Health Research Project LKZ2022019YangZhou Municipal Science and Technology Bureau (YangZhou Science and Technology Bureau) YZ2021078
6 · The paper itself

Abstract

Esophageal squamous cell carcinoma (ESCC) is one of the most predominant subtypes of esophageal cancer. The characteristics of the gut microbiome and its metabolites from patients with ESCC have not been adequately studied and discussed. In this study, 40 fecal samples (20 from ESCC patients and 20 from healthy controls) were analyzed by 16S rRNA gene sequencing and untargeted metabolomics. The data sets were analyzed individually and synthesized using various bioinformatics methods. Alpha and beta diversity indicated significant differences in microbial diversity and abundance between ESCC and healthy control feces. At the genus level, the abundance of

Indexed as

BacteriaEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaFecesGastrointestinal MicrobiomeMetabolomicsAdultAgedBiomarkers, TumorFemaleHumansMaleMiddle AgedRNA, Ribosomal, 16SBiomarkers, TumorRNA, Ribosomal, 16S16S rRNA amplicon sequencingbiomarkersesophageal squamous cell carcinomagut microbiomemetabolomics

Identifiers

PMID38497715
PMCPMC11064534
OpenAlexW4392915804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.