Evidence map›Paper›PMID 38497709›Full record

ArticleBioanalysis2024

An LC-MS/MS method for determination of the bromodomain inhibitor ZEN-3694 and its metabolite ZEN-3791 in human plasma.

Ye Feng, Haider Mahdi, Richard Piekarz, Jan H Beumer, Timothy W Synold

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioanalysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ye FengDepartment of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA 91010, USA.
Haider MahdiDepartment of Obstetrics, Gynecology & Reproductive Sciences & Magee Women's Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Richard PiekarzInvestigational Drug Branch, Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD 20892, USA.
Jan H BeumerUPMC Hillman Cancer Center, Hillman Research Pavilion, Pittsburgh, PA 15232, USA.
Timothy W SynoldDepartment of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA 91010, USA.ORCID 0000-0002-4075-2544

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
NCI ET-CTN with Phase i Emphasis at UPCIUM1CA186690 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD, Farshid Dayyani · 2014 to 2026
$9.1M
PITT-CAL ETCTN PK Resource LaboratoryU24CA247643 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TIMOTHY W SYNOLD, Raman Venkataramanan · 2020 to 2026
$3.6M
Cancer Pharmacokinetics Research SpecialistR50CA211241 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PARISE, ROBERT · 2016 to 2025
$1.8M
National Cancer Institute of the National Institutes of Health U24CA247643, UM1CA186690 and P30CA033572NCI NIH HHS P30 CA033572NCI NIH HHS P30 CA047904NCI NIH HHS R50 CA211241NCI NIH HHS U24 CA247643NCI NIH HHS UM1 CA186690NIH HHS P30CA033572, U24CA247643, UM1CA186690
6 · The paper itself

Abstract

We have developed and validated a novel LC-MS/MS method for the simultaneous quantification of ZEN-3694 and its active metabolite ZEN-3791 in human plasma after protein precipitation. Stable isotope-labeled versions were used as internal standards. Chromatographic separation was achieved on a Kinetex C18 column using 0.1% formic acid in H

Indexed as

Liquid Chromatography-Mass SpectrometryHumansTandem Mass SpectrometryassayBET bromodomain inhibitorchromatographyclinicalLC–MSmass spectrometryZEN-3694ZEN-3791

Identifiers

PMID38497709
PMCPMC11216518

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.