Evidence map›Paper›PMID 38497569›Full record

ArticleCancer2025

The role of surgery and deescalation for HPV-related oropharyngeal cancer.

Kevin J Contrera, Mihir R Patel, Barbara Burtness, Ranee Mehra, Robert L Ferris

Open access · hybridAbstract readEditorial
In one paragraph

Article in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Review
  4. Redefining oropharyngeal cancer in the HPV era: integrating precision medicine and immunotherapeutic frontiers.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  5. Article
  6. [Management and consideration of positive surgical margins in locally advanced oropharyngeal squamous cell carcinoma treated with oral robotic surgery].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Kevin J ContreraUPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-2570-1706
Mihir R PatelWinship Cancer Institute of Emory University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-6477-9728
Barbara BurtnessYale School of Medicine and Yale Cancer Center, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0003-4660-1859
Ranee MehraUniversity of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland, USA.
Robert L FerrisUPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-6605-2071
UPMC Hillman Cancer Center · USEmory University · USUniversity of Maryland, Baltimore · USYale Cancer Center · US

Funding

Project-006U10CA180820 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer · 2014 to 2026
$167.6M
Mechanistic connection between HPV-specific TCRs and therapeutic responses to ICI in HPV+ HNSCCR01CA282074 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert L. Ferris, Jing Hong Wang · 2024 to 2026
$2.0M
NCI NIH HHS R01 CA282074NCI NIH HHS U10 CA180820
6 · The paper itself

Abstract

Recently published and ongoing trials are helping to define the role of transoral robotic surgery for oropharyngeal cancer. Evidence to date supports the use of surgery as a valuable tool in the multidisciplinary deescalation of low-risk human papillomavirus-related oropharyngeal squamous cell carcinoma.

Indexed as

Carcinoma, Squamous CellOropharyngeal NeoplasmsPapillomavirus InfectionsRobotic Surgical ProceduresHumansPapillomaviridaehead and neck cancerhuman papillomavirusoropharyngeal canceroropharynxsquamous cell carcinomatransoral robotic surgery

Identifiers

PMID38497569
PMCPMC11736833
OpenAlexW4392912799

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.