Evidence map›Paper›PMID 38497529›Full record

ReviewCNS neuroscience & therapeutics2024

Isolation and usage of exosomes in central nervous system diseases.

Wenjing Wang, Hong Sun, Huijuan Duan, Gang Sheng, Na Tian, Dingyi Liu, Zhaogang Sun

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
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  7. Article
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  13. Exosomes as a biomarker in postoperative complications: a literature review.Frontiers in cell and developmental biology · 2026
    Review
  14. MicroRNA-126 as an endogenous molecule for hypoxic/ischemic tolerance in neuroprotection.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Wenjing WangBeijing Chest Hospital Affiliated to Capital Medical University, Beijing, China.ORCID 0009-0005-6436-991X
Hong SunBeijing Chest Hospital Affiliated to Capital Medical University, Beijing, China.
Huijuan DuanBeijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
Gang ShengBeijing Chest Hospital Affiliated to Capital Medical University, Beijing, China.
Na TianBeijing Chest Hospital Affiliated to Capital Medical University, Beijing, China.
Dingyi LiuBeijing Chest Hospital Affiliated to Capital Medical University, Beijing, China.
Zhaogang SunBeijing Chest Hospital Affiliated to Capital Medical University, Beijing, China.
Capital Medical University · CNBeijing Chest Hospital · CN

Funding

Capital Health Research and Development of Special Fund 2022-1G-2161National Natural Science Foundation of China 82272347
6 · The paper itself

Abstract

backgroundExosomes are vesicles secreted by all types of mammalian cells. They are characterized by a double-layered lipid membrane structure. They serve as carriers for a plethora of signal molecules, including DNA, RNA, proteins, and lipids. Their unique capability of effortlessly crossing the blood-brain barrier underscores their critical role in the progression of various neurological disorders. This includes, but is not limited to, diseases such as Alzheimer's, Parkinson's, and ischemic stroke. Establishing stable and mature methods for isolating exosomes is a prerequisite for the study of exosomes and their biomedical significance. The extraction technologies of exosomes include differential centrifugation, density gradient centrifugation, size exclusion chromatography, ultrafiltration, polymer coprecipitation, immunoaffinity capture, microfluidic, and so forth. Each extraction technology has its own advantages and disadvantages, and the extraction standards of exosomes have not been unified internationally.

aimsThis review aimed to showcase the recent advancements in exosome isolation techniques and thoroughly compare the advantages and disadvantages of different methods. Furthermore, the significant research progress made in using exosomes for diagnosing and treating central nervous system (CNS) diseases has been emphasized.

conclusionThe varying isolation methods result in differences in the concentration, purity, and size of exosomes. The efficient separation of exosomes facilitates their widespread application, particularly in the diagnosis and treatment of CNS diseases.

Indexed as

Central Nervous System DiseasesExosomesHumansProteinsProteinsbiomarkercentral nervous systemdiagnosisexosomesisolation method

Identifiers

PMID38497529
PMCPMC10945885
OpenAlexW4392913470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.