Evidence map›Paper›PMID 38497429›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Delineating cognitive resilience using fractal regulation: Cross-sectional and longitudinal evidence from the Rush Memory and Aging Project.

Peng Li, Chenlu Gao, Lei Yu, Lei Gao, Ruixue Cai, David A Bennett, Julie A Schneider, Aron S Buchman, Kun Hu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Peng LiDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-4684-4909
Chenlu GaoDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Lei YuRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Lei GaoDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Ruixue CaiDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Julie A SchneiderRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Aron S BuchmanRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Kun HuDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Broad Institute · USRush University Medical Center · USBrigham and Women's Hospital · US

Funding

EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Integrative Motor Activity Biomarker for the Risk of Alzheimer's RiskRF1AG064312 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI HU, KUN · 2019 to 2019
$3.6M
Circadian Disturbance and Dementia in Latin AmericaR01AG083799 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Kun Hu, Agustin M. Ibanez · 2023 to 2026
$3.0M
Fractal motor activity regulation and the risk for Alzheimers disease in middle-to-old aged adultsRF1AG059867 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI HU, KUN · 2018 to 2018
$2.7M
Circadian Multiscale Activity Regulation and the Risk for Delirium in Elderly Hospitalized PatientsR03AG067985 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GAO, LEI · 2020 to 2021
$268k
Alzheimer's Association AACSF-23-1148490Brigham Research InstituteBrightFocus Foundation Alzheimer's Research Program A2020886SDepartment of Anesthesia, Critical Care and Pain Medicine at Massachusetts General HospitalNational Institute on Aging (NIA) R01AG083799National Institute on Aging (NIA) R01AG17917National Institute on Aging (NIA) RF1AG064312NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG083799NIA NIH HHS R03 AG067985NIA NIH HHS RF1 AG059867NIA NIH HHS RF1 AG064312
6 · The paper itself

Abstract

introductionDegradation of fractal patterns in actigraphy independently predicts dementia risk. Such observations motivated the study to understand the role of fractal regulation in the context of neuropathologies.

methodsWe examined associations of fractal regulation with neuropathologies and longitudinal cognitive changes in 533 older participants who were followed annually with actigraphy and cognitive assessments until death with brain autopsy performed. Two measures for fractal patterns were extracted from actigraphy, namely, α

resultsWe found that larger α DISCUSSION: Fractal patterns may be used as a biomarker for cognitive resilience against dementia-related neuropathologies.

Indexed as

Cognitive DysfunctionFractalsActigraphyAgedAged, 80 and overAgingBrainCerebrovascular DisordersCognitionCross-Sectional StudiesFemaleHumansLewy Body DiseaseLongitudinal StudiesMaleNeuropsychological TestsactigraphyAlzheimer's diseasecognitionreserveresiliencewearable

Identifiers

PMID38497429
PMCPMC11095481
OpenAlexW4392913992

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.