Evidence map›Paper›PMID 38497236›Full record

ArticleAge and ageing2024

Delirium is more common and associated with worse outcomes in Parkinson's disease compared to older adult controls: results of two prospective longitudinal cohort studies.

Florence Gerakios, Alison J Yarnall, Gemma Bate, Laura Wright, Daniel Davis, Blossom C M Stephan, Louise Robinson, Carol Brayne, Glenn Stebbins, John-Paul Taylor and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Age and ageing, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Observational
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 3 countries.

Florence GerakiosTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0001-7162-8928
Alison J YarnallTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0002-3126-9163
Gemma BateTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0002-8588-6124
Laura WrightTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0002-0558-7811
Daniel DavisMRC Unit for Lifelong Health and Ageing, University College London, London, UK.ORCID 0000-0002-1560-1955
Blossom C M StephanInstitute of Mental Health, School of Medicine, Nottingham University, Nottingham, UK.ORCID 0000-0002-1235-360X
Louise RobinsonPopulation Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0003-0209-2503
Carol BrayneDepartment of Psychiatry, University of Cambridge, Cambridge, UK.ORCID 0000-0001-5307-663X
Glenn StebbinsDepartment of Neurological Sciences, Rush University Medical Center, Chicago, USA.ORCID 0000-0001-7905-9336
John-Paul TaylorTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0001-7958-6558
David J BurnTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0001-7658-1209
Louise M AllanCentre for Research in Ageing and Cognitive Health, University of Exeter, Exeter, UK.ORCID 0000-0002-8912-4901
Sarah J RichardsonTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Rachael A LawsonTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0003-2608-8285
Newcastle University · GBNIHR Newcastle Biomedical Research Centre · GBNewcastle upon Tyne Hospitals NHS Foundation Trust · GBMRC Unit for Lifelong Health and Ageing · GBRush University Medical Center · USUniversity of Cambridge · GBUniversity of Exeter · GBUniversity of Nottingham · GB

Funding

Alzheimer's Society 239Alzheimer's Society 294Wellcome Trust
6 · The paper itself

Abstract

backgroundInpatient prevalence of Parkinson's disease (PD) delirium varies widely across the literature. Delirium in general older populations is associated with adverse outcomes, such as increased mortality, dementia, and institutionalisation. However, to date there are no comprehensive prospective studies in PD delirium. This study aimed to determine delirium prevalence in hospitalised PD participants and the association with adverse outcomes, compared to a control group of older adults without PD.

methodsParticipants were hospitalised inpatients from the 'Defining Delirium and its Impact in Parkinson's Disease' and the 'Delirium and Cognitive Impact in Dementia' studies comprising 121 PD participants and 199 older adult controls. Delirium was diagnosed prospectively using the Diagnostic and Statistical Manual of Mental Disorders 5th Edition criteria. Outcomes were determined by medical note reviews and/or home visits 12 months post hospital discharge.

resultsDelirium was identified in 66.9% of PD participants compared to 38.7% of controls (p < 0.001). In PD participants only, delirium was associated with a significantly higher risk of mortality (HR = 3.3 (95% confidence interval [CI] = 1.3-8.6), p = 0.014) and institutionalisation (OR = 10.7 (95% CI = 2.1-54.6), p = 0.004) 12 months post-discharge, compared to older adult controls. However, delirium was associated with an increased risk of developing dementia 12 months post-discharge in both PD participants (OR = 6.1 (95% CI = 1.3-29.5), p = 0.024) and in controls (OR = 13.4 (95% CI = 2.5-72.6), p = 0.003).

conclusionDelirium is common in hospitalised PD patients, affecting two thirds of patients, and is associated with increased mortality, institutionalisation, and dementia. Further research is essential to understand how to accurately identify, prevent and manage delirium in people with PD who are in hospital.

Indexed as

DeliriumDementiaParkinson DiseaseAftercareAgedHumansLongitudinal StudiesPatient DischargeProspective StudiesDeliriumInstitutionalisationMortalityOlder peopleOutcomesParkinson's disease

Identifiers

PMID38497236
PMCPMC10945294
OpenAlexW4392918571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.