Evidence map›Paper›PMID 38497230›Full record

ArticleHypertension (Dallas, Tex. : 1979)2024

Role of Raptor Gene Variants in Hypertension: Influence on Blood Pressure Independent of Salt Intake in White Population.

Hayat Aljaibeji, Mahyar Heydarpour, Ana Maria Stanton, Jonathan S Williams, Luminita H Pojoga, Jose R Romero, Gordon H Williams

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hayat AljaibejiDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA (H.A., M.H., A.M.S., J.S.W., L.H.P., J.R.R., G.H.W.).ORCID 0000-0002-1716-0743
Mahyar HeydarpourDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA (H.A., M.H., A.M.S., J.S.W., L.H.P., J.R.R., G.H.W.).ORCID 0000-0002-5741-367X
Ana Maria StantonDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA (H.A., M.H., A.M.S., J.S.W., L.H.P., J.R.R., G.H.W.).ORCID 0000-0001-7197-971X
Jonathan S WilliamsDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA (H.A., M.H., A.M.S., J.S.W., L.H.P., J.R.R., G.H.W.).ORCID 0000-0001-7152-765X
Luminita H PojogaDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA (H.A., M.H., A.M.S., J.S.W., L.H.P., J.R.R., G.H.W.).ORCID 0000-0002-9448-6333
Jose R RomeroDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA (H.A., M.H., A.M.S., J.S.W., L.H.P., J.R.R., G.H.W.).ORCID 0000-0001-8225-0772
Gordon H WilliamsDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA (H.A., M.H., A.M.S., J.S.W., L.H.P., J.R.R., G.H.W.).
Brigham and Women's Hospital · US

Funding

TRAINING PROGRAM IN HYPERTENSIONT32HL007609 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ADLER, GAIL KURR · 1985 to 2022
$10.2M
Striatin, Aldosterone and HypertensionR56HL114765 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WILLIAMS, GORDON H · 2018 to 2018
$838k
NHLBI NIH HHS R56 HL114765NHLBI NIH HHS T32 HL007609
6 · The paper itself

Abstract

backgroundThe mTOR (mechanistic target of rapamycin) is an essential regulator of fundamental biological processes. mTOR forms 2 distinct complexes, mTORC1 (mTOR complex 1) when it binds with RAPTOR (Regulatory-associated Protein of mTOR) and mTORC2 (mTOR complex 2) when it associates with RICTOR (Rapamycin-insesitive companion of mTOR). Due to the previous link between the mTOR pathway, aldosterone, and blood pressure (BP), we anticipated that variants in the mTOR complex might be associated with salt-sensitive BP.

methodsBP and other parameters were assessed after a one-week liberal Na

resultsThe analysis revealed a significant association between a single nucleotide variants within the

conclusionsThe

Indexed as

Blood PressureHypertensionRegulatory-Associated Protein of mTORSodium Chloride, DietaryCarrier ProteinsFemaleHumansMaleMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2NucleotidesRapamycin-Insensitive Companion of mTOR ProteinSirolimusTOR Serine-Threonine KinasesWhite PeopleCarrier ProteinsMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2NucleotidesRapamycin-Insensitive Companion of mTOR ProteinRegulatory-Associated Protein of mTORRPTOR protein, humanSirolimusSodium Chloride, DietaryTOR Serine-Threonine Kinasesaldosteroneblood pressurehypertensionmTOR, rictornucleotideraptor

Identifiers

PMID38497230
PMCPMC11023780
OpenAlexW4392916837

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.