Evidence map›Paper›PMID 38497111›Full record

ArticleAmerican journal of physiology. Cell physiology2024

A novel approach to determine the critical survival threshold of cellular oxygen within spheroids via integrating live/dead cell imaging with oxygen modeling.

Kuang-Ming Shang, Hiroyuki Kato, Nelson Gonzalez, Fouad Kandeel, Yu-Chong Tai, Hirotake Komatsu

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Oxygen dynamics and delivery strategies to enhance beta cell replacement therapy.American journal of physiology. Cell physiology · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Kuang-Ming ShangDepartment of Medical Engineering, California Institute of Technology, Pasadena, California, United States.ORCID 0000-0001-5065-7607
Hiroyuki KatoDepartment of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute of City of Hope, Duarte, California, United States.
Nelson GonzalezDepartment of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute of City of Hope, Duarte, California, United States.
Fouad KandeelDepartment of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute of City of Hope, Duarte, California, United States.
Yu-Chong TaiDepartment of Medical Engineering, California Institute of Technology, Pasadena, California, United States.
Hirotake KomatsuDepartment of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute of City of Hope, Duarte, California, United States.ORCID 0000-0003-0876-4809
City of Hope · USCalifornia Institute of Technology · US

Funding

Vascular network-mimetic oxygen-transporting mesh for islet graftR03DK129958 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI KOMATSU, HIROTAKE · 2021 to 2022
$353k
HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) R03DK129958-01JDRF (JDRF International) 3-SRA-2021-1073-S-BNIDDK NIH HHS R03 DK129958Nora Eccles Treadwell Foundation NA
6 · The paper itself

Abstract

Defining the oxygen level that induces cell death within 3-D tissues is vital for understanding tissue hypoxia; however, obtaining accurate measurements has been technically challenging. In this study, we introduce a noninvasive, high-throughput methodology to quantify critical survival partial oxygen pressure (pO

Indexed as

Islets of LangerhansOxygenCell HypoxiaCell SurvivalHumansHypoxiaSpheroids, CellularOxygencell survivalcomputational simulationhypoxiapancreatic isletsviability assay

Identifiers

PMID38497111
PMCPMC11193515
OpenAlexW4392918186

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.