Evidence map›Paper›PMID 38497056›Full record

ArticleBio-design and manufacturing2024

Biofabrication of nanocomposite-based scaffolds containing human bone extracellular matrix for the differentiation of skeletal stem and progenitor cells.

Yang-Hee Kim, Janos M Kanczler, Stuart Lanham, Andrew Rawlings, Marta Roldo, Gianluca Tozzi, Jonathan I Dawson, Gianluca Cidonio, Richard O C Oreffo

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bio-design and manufacturing, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Yang-Hee KimFaculty of Medicine, Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD UK.
Janos M KanczlerFaculty of Medicine, Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD UK.
Stuart LanhamFaculty of Medicine, Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD UK.
Andrew RawlingsFaculty of Medicine, Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD UK.
Marta RoldoSchool of Pharmacy and Biomedical Science, University of Portsmouth, Portsmouth, PO1 2DT UK.
Gianluca TozziSchool of Engineering, Faculty of Engineering and Science, University of Greenwich, Greenwich, ME4 4TB UK.
Jonathan I DawsonFaculty of Medicine, Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD UK.
Gianluca CidonioFaculty of Medicine, Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD UK.ORCID 0000-0002-9445-6994
Richard O C OreffoFaculty of Medicine, Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD UK.ORCID 0000-0001-5995-6726
University of Southampton · GBItalian Institute of Technology · ITUniversity of Greenwich · GBUniversity of Portsmouth · GB

Funding

Medical Research Council MR/K026682/1Medical Research Council MR/L012626/1Medical Research Council MR/R015651/1
6 · The paper itself

Abstract

Autograft or metal implants are routinely used in skeletal repair. However, they fail to provide long-term clinical resolution, necessitating a functional biomimetic tissue engineering alternative. The use of native human bone tissue for synthesizing a biomimetic material ink for three-dimensional (3D) bioprinting of skeletal tissue is an attractive strategy for tissue regeneration. Thus, human bone extracellular matrix (bone-ECM) offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells (HBMSCs) to proliferate and differentiate along the osteogenic lineage. In this study, we engineered a novel material ink (LAB) by blending human bone-ECM (B) with nanoclay (L, Laponite Graphic abstract: Supplementary Information: The online version contains supplementary material available at 10.1007/s42242-023-00265-z.

Indexed as

3D bioprintingBoneExtracellular matrixNanoclay

Identifiers

PMID38497056
PMCPMC10937808
OpenAlexW4392470564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.