ArticleTranslational lung cancer research2024
Fibre-based fluorescence-lifetime imaging microscopy: a real-time biopsy guidance tool for suspected lung cancer.
Article in Translational lung cancer research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Label-free pathological subtyping of non-small cell lung cancer using deep classification and virtual immunohistochemical staining.NPJ digital medicine · 2026Article
- Hidden in visible light: spectral-temporal unmixing of lung tissue autofluorescence in a fibre-based system.Biomedical optics express · 2026Article
- Defining the optimal imaging time point for fluorescence-lifetime-based tumor identification using the non-targeting near-infrared dye indocyanine green and post-processed high-dynamic-range images.Biomedical optics express · 2026Article
- Article
- Adaptive fluorescence lifetime imaging with per-pixel signal optimization and flexible scanning.Biomedical optics express · 2025Article
- Identification of colorectal malignancies enabled by phasor-based autofluorescence lifetime macroimaging and ensemble learning.Biophotonics discovery · 2025Article
- Widefield frequency-domain autofluorescence lifetime imaging for detecting breast cancer in murine xenograft tumor tissues.Journal of biomedical optics · 2025Article
- Light-field tomographic fluorescence lifetime imaging microscopy.Research square · 2023Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Lung cancer is the most common cause of cancer-related deaths worldwide. Early detection improves outcomes, however, existing sampling techniques are associated with suboptimal diagnostic yield and procedure-related complications. Autofluorescence-based fluorescence-lifetime imaging microscopy (FLIM), a technique which measures endogenous fluorophore decay rates, may aid identification of optimal biopsy sites in suspected lung cancer. Our fibre-based fluorescence-lifetime imaging system, utilising 488 nm excitation, which is deliverable via existing diagnostic platforms, enables real-time visualisation and lifetime analysis of distal alveolar lung structure. We evaluated the diagnostic accuracy of the fibre-based fluorescence-lifetime imaging system to detect changes in fluorescence lifetime in freshly resected
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Registered trials
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