Evidence map›Paper›PMID 38496666›Full record

ArticlebioRxiv : the preprint server for biology2024

Protective effects of nicotinamide in a mouse model of glaucoma DBA/2 studied by second-harmonic generation microscopy.

Vinessia Boodram, Hyungsik Lim

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Vinessia BoodramDepartment of Physics and Astronomy, Hunter College of the City University of New York, New York, NY 10065.
Hyungsik LimDepartment of Physics and Astronomy, Hunter College of the City University of New York, New York, NY 10065.
City University of New York · US

Funding

Imaging cell-type-specific transcription in living mammalian brainR35GM140841 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI LIM, HYUNGSIK · 2021 to 2025
$2.0M
Method for Large-scale Quantitative Analysis of Myelin in Living AnimalsSC1GM121198 · NIGMS · HUNTER COLLEGE · PI LIM, HYUNGSIK · 2017 to 2020
$1.4M
Microtubule Deficit in GlaucomaR21EY033047 · NEI · TRUSTEES OF INDIANA UNIVERSITY · PI LIM, HYUNGSIK · 2021 to 2022
$422k
NEI NIH HHS R21 EY033047NIGMS NIH HHS R35 GM140841NIGMS NIH HHS SC1 GM121198
6 · The paper itself

Abstract

Glaucoma is a blinding disease where the retinal ganglion cells and their axons degenerate. Degradation of axonal microtubules is thought to play a critical role in the pathogenesis, but the mechanism is unknown. Here we investigate whether microtubule disruption in glaucoma can be alleviated by metabolic rescue. The morphology and integrity of microtubules of the retinal nerve fibers were evaluated by second-harmonic generation microscopy in a mouse model of glaucoma, DBA/2, which received a dietary supplement of nicotinamide to reduce metabolic stress. It was compared with control DBA/2, which did not receive nicotinamide, and non-glaucomatous DBA/2-

Identifiers

PMID38496666
PMCPMC10942456
OpenAlexW4392657290

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.