Evidence map›Paper›PMID 38496653›Full record

ArticlebioRxiv : the preprint server for biology2024

Comprehensive analyses of a large human gut Bacteroidales culture collection reveal species and strain level diversity and evolution.

Zhenrun J Zhang, Cody G Cole, Michael J Coyne, Huaiying Lin, Nicholas Dylla, Rita C Smith, Emily Waligurski, Ramanujam Ramaswamy, Che Woodson, Victoria Burgo and 9 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Zhenrun J ZhangDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.ORCID 0000-0002-2124-5539
Cody G ColeDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Michael J CoyneDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Huaiying LinDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Nicholas DyllaDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Rita C SmithDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Emily WaligurskiDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Ramanujam RamaswamyDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Che WoodsonDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Victoria BurgoDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Jessica C LittleDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
David MoranDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Amber RoseDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Mary McMillinDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Emma McSpaddenDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Anitha SundararajanDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Ashley M SidebottomDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Eric G PamerDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Laurie E ComstockDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
University of Chicago · US

Funding

T LYMPHOCYTE SUBSET FUNCTION POST-TRANSPLANTATIONP01CA023766 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI PAMER, ERIC G. · 1985 to 2023
$59.0M
ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI LIU, CAMBRIAN YANGSHAO · 1990 to 2025
$29.8M
Probing short and long term consequences of Small and Large Bowel Microbiota Transplants on Host Physiology: Implications for the development of future live biotherapeuticsR01DK138072 · NIDDK · UNIVERSITY OF CHICAGO · PI EUGENE B CHANG, Kristina Brooke Martinez-Guryn · 2024 to 2026
$2.1M
NCI NIH HHS P01 CA023766NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK138072
6 · The paper itself

Abstract

Species of the Bacteroidales order are among the most abundant and stable bacterial members of the human gut microbiome with diverse impacts on human health. While Bacteroidales strains and species are genomically and functionally diverse, order-wide comparative analyses are lacking. We cultured and sequenced the genomes of 408 Bacteroidales isolates from healthy human donors representing nine genera and 35 species and performed comparative genomic, gene-specific, mobile gene, and metabolomic analyses. Families, genera, and species could be grouped based on many distinctive features. However, we also show extensive DNA transfer between diverse families, allowing for shared traits and strain evolution. Inter- and intra-specific diversity is also apparent in the metabolomic profiling studies. This highly characterized and diverse Bacteroidales culture collection with strain-resolved genomic and metabolomic analyses can serve as a resource to facilitate informed selection of strains for microbiome reconstitution.

Identifiers

PMID38496653
PMCPMC10942478
OpenAlexW4392633782

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.