Evidence map›Paper›PMID 38496651›Full record

ArticlebioRxiv : the preprint server for biology2024

Comprehensive analysis of CXXX sequence space reveals that

Anushka Sarkar, Emily R Hildebrandt, Khushi V Patel, Emily T Mai, Sumil S Shah, June H Kim, Walter K Schmidt

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Anushka SarkarDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602.
Emily R HildebrandtDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602.
Khushi V PatelDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602.
Emily T MaiDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602.
Sumil S ShahDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602.
June H KimDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602.
Walter K SchmidtDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602.ORCID 0000-0002-3359-3434
University of Georgia · US

Funding

Determining the scope of prenylatable protein sequencesR01GM132606 · NIGMS · UNIVERSITY OF GEORGIA · PI KANNAN, NATARAJAN, SCHMIDT, WALTER K · 2019 to 2022
$1.6M
NIGMS NIH HHS R01 GM132606
6 · The paper itself

Abstract

Many proteins undergo a post-translational lipid attachment, which increases their hydrophobicity, thus strengthening their membrane association properties or aiding in protein interactions. Geranylgeranyltransferase-I (GGTase-I) is an enzyme involved in a three-step post-translational modification (PTM) pathway that attaches a 20-carbon lipid group called geranylgeranyl at the carboxy-terminal cysteine of proteins ending in a canonical CaaL motif (C - cysteine, a - aliphatic, L - often leucine, but can be phenylalanine, isoleucine, methionine, or valine). Genetic approaches involving two distinct reporters were employed in this study to assess

Indexed as

genetic screengeranylgeranyltransferase-Inext-generation sequencingtarget specificity

Identifiers

PMID38496651
PMCPMC10942308
OpenAlexW4392571059

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.