Evidence map›Paper›PMID 38496643›Full record

ArticlebioRxiv : the preprint server for biology2024

Zinc Alpha-2-Glycoprotein (ZAG/AZGP1) secreted by triple-negative breast cancer promotes tumor microenvironment fibrosis.

Surbhi Verma, Stephanie Dudics Giagnocavo, Meghan C Curtin, Menusha Arumugam, Sandra M Osburn-Staker, Guoying Wang, Aaron Atkinson, David A Nix, David H Lum, James E Cox and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Surbhi VermaDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Stephanie Dudics GiagnocavoDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Meghan C CurtinDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Menusha ArumugamDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Sandra M Osburn-StakerMetabolomics, Proteomics and Mass Spectrometry Core, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Guoying WangHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Aaron AtkinsonHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
David A NixHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
David H LumHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
James E CoxDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Keren I HilgendorfDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.ORCID 0000-0001-8377-8384
University of Utah · US

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
Q-ToF Mass Spectrometer for the University of Utah MS and Proteomics CoreS10OD018210 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2015 to 2015
$530k
NCI NIH HHS P30 CA042014NIH HHS S10 OD018210
6 · The paper itself

Abstract

Obesity is a predisposition factor for breast cancer, suggesting a localized, reciprocal interaction between breast cancer cells and the surrounding mammary white adipose tissue. To investigate how breast cancer cells alter the composition and function of adipose tissue, we screened the secretomes of ten human breast cancer cell lines for the ability to modulate the differentiation of adipocyte stem and progenitor cells (ASPC). The screen identified a key adipogenic modulator, Zinc Alpha-2-Glycoprotein (ZAG/AZGP1), secreted by triple-negative breast cancer (TNBC) cells. TNBC-secreted ZAG inhibits adipogenesis and instead induces the expression of fibrotic genes. Accordingly, depletion of ZAG in TNBC cells attenuates fibrosis in white adipose tissue and inhibits tumor growth. Further, high expression of ZAG in TNBC patients, but not other clinical subtypes of breast cancer, is linked to poor prognosis. Our findings suggest a role of TNBC-secreted ZAG in promoting the transdifferentiation of ASPCs into cancer-associated fibroblasts to support tumorigenesis.

Indexed as

adipocyte stem and progenitor cellsadipose tissueAZGP1cancer-associated fibroblastsfibrosissecretometriple-negative breast cancertumor microenvironmentZAGZinc Alpha-2-Glycoprotein

Identifiers

PMID38496643
PMCPMC10942361
OpenAlexW4392592335

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.