Evidence map›Paper›PMID 38496599›Full record

ArticlebioRxiv : the preprint server for biology2024

Targeting G9a translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae.

Adil Muneer, Ling Xie, Xuping Xie, Feng Zhang, John A Wrobel, Yan Xiong, Xufen Yu, Charles Wang, Ciprian Gheorghe, Ping Wu and 6 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Adil Muneer
Ling Xie
Xuping XieORCID 0000-0003-0918-016X
Feng Zhang
John A Wrobel
Yan Xiong
Xufen Yu
Charles Wang
Ciprian Gheorghe
Ping Wu
Juan Song
Guo-Li Ming
Jian Jin
Hongjun Song
Pei-Yong Shi
Xian Chen
University of North Carolina at Chapel Hill · USIcahn School of Medicine at Mount Sinai · USUniversity of Pennsylvania · USJohn Sealy Hospital · USLoma Linda University · US

Funding

Deciphering the non-canonical function of the histone methyltransferase G9a in the etiology of ADR21AG071229 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHEN, XIAN · 2021 to 2022
$428k
NIA NIH HHS R21 AG071229
6 · The paper itself

Abstract

By largely unknown mechanism(s), SARS-CoV-2 hijacks the host translation apparatus to promote COVID-19 pathogenesis. We report that the histone methyltransferase G9a noncanonically regulates viral hijacking of the translation machinery to bring about COVID-19 symptoms of hyperinflammation, lymphopenia, and blood coagulation. Chemoproteomic analysis of COVID-19 patient peripheral mononuclear blood cells (PBMC) identified enhanced interactions between SARS-CoV-2-upregulated G9a and distinct translation regulators, particularly the N

Identifiers

PMID38496599
PMCPMC10942352
OpenAlexW4392558880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.