ArticlemedRxiv : the preprint server for health sciences2024
A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations.
Open access · greenAbstract readPreprint
In one paragraph
Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
- Updated by
Authors and funding
163 authors at 20 institutions in 15 countries.
Pavithra NagarajanDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-0036-9970
Thomas W WinklerDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.ORCID 0000-0003-0292-5421
Amy R BentleyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-0827-9101
Clint L MillerCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesvil le, VA, USA.ORCID 0000-0003-4276-3607
Aldi T KrajaUniversity of Mississippi Medical Center, Jackson, MS, USA.
Karen SchwanderDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Songmi LeeBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.
Wenyi WangDepartment of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
Michael R BrownHuman Genetics Center, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.
John L MorrisonDivision of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Ayush GiriDivision of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-7786-4670
Jeffrey R O'ConnellDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Traci M BartzCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Lisa de Las FuentesCardiovascular Division, Department of Medicine, Washington University School of Medicine in St. Louis, MO, USA.ORCID 0000-0002-4689-325X
Valborg GudmundsdottirIcelandic Heart Association, Kopavogur, Iceland.ORCID 0000-0002-7459-1603
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Sarah E HarrisDepartment of Psychology, The University of Edinburgh, Edinburgh, UK.
Zhijie HuangDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, US.
Mart KalsEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Minjung KhoGraduate School of Data Science, Seoul National University, Seoul, South Korea.
Christophe LefevreDepartment of Data Sciences, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Jian'an LuanMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.ORCID 0000-0002-7200-5455
Massimo ManginoDepartment of Twin Research, King's College London, London, UK.ORCID 0000-0002-2167-7470
Yuri MilaneschiDepartment of Psychiatry, Amsterdam UMC/Vrije universiteit, Amsterdam, Netherlands.ORCID 0000-0002-3697-6617
Nicholette D PalmerDepartment of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Varun RaoDivision of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, USA.
Rainer RauramaaKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Botong ShenLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
Stefan StadlerDepartment of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
Quan SunDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jingxian TangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Sébastien ThériaultDepartment of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Quebec City, Qc, Canada.ORCID 0000-0003-1893-8307
Adriaan van der GraafStatistical Genetics Group, Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Yujie WangDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Stefan WeissDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Kenneth E WestermanDepartment of Medicine, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7619-1868
Qian YangMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Tabara YasuharuGraduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan.
Wei ZhaoSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Wanying ZhuDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Drew AltschulDepartment of Psychology, The University of Edinburgh, Edinburgh, UK.
Md Abu Yusuf AnsariDepartment of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.
Pramod AnuguJackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA.
Anna D Argoty-PantojaDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Michael ArztDepartment of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
Hugues AschardDepartment of Computational Biology, F-75015 Paris, France Institut Pasteur, Université Paris Cité, Paris, France.ORCID 0000-0002-7554-6783
John R AttiaSchool of Medicine and Public Health, College of Health Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia.
Lydia BazzannoDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, US.
Max A BreyerDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Brian E CadeDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0003-1424-0673
Hung-Hsin ChenDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Zekai ChenDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Paul S de VriesHuman Genetics Center, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.
Latchezar M DimitrovDepartment of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Anh DoCenter for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.
Jiawen DuDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Charles T DupontDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Todd L EdwardsBiomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626), Department of Veterans Affairs/ Nashville, TN, USA.
Michele K EvansLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
Tariq FaquihDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Stephan B FelixDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Susan P Fisher-HochSchool of Public Health, The University of Texas Health Science Center at Houston (UTHealth), Brownsville, TX, USA.
James S FloydCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Mariaelisa GraffDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Charles GuCenter for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.
Dongfeng GuShenzhen Key Laboratory of Cardiovascular Health and Precision Medicine, Southern University of Science an d Technology, Shenzhen, China.
Kristen G HairstonDepartment of Endocrinology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Anthony J HanleyDepartment of Nutritional Sciences, University of Toronto, Toronto, ON, Canada.
Iris M HeidDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Sami HeikkinenInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Kuopio.
Heather M HighlandDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Michelle M HoodDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Mika KähönenFinnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere, Finland.
Carrie A Karvonen-GutierrezDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Takahisa KawaguchiCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.ORCID 0000-0001-7781-7404
Setoh KazuyaGraduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan.
Tanika N KellyDivision of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, USA.ORCID 0000-0002-7348-4451
Pirjo KomulainenKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Daniel LevyPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Henry J LinThe Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Peter Y LiuThe Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Pedro Marques-VidalDepartment of Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Joseph B McCormickSchool of Public Health, The University of Texas Health Science Center at Houston (UTHealth), Brownsville, TX, USA.ORCID 0000-0002-5844-8102
Hao MeiDepartment of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.
James B MeigsDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Cristina MenniDepartment of Twin Research, King's College London, London, UK.
Kisung NamGraduate School of Data Science, Seoul National University, Seoul, South Korea.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Natasha L PachecoLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
Lauren E PettyDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Hannah G PolikowskyDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Michael A ProvinceDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Laura M RaffieldDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Olli T RaitakariCentre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.ORCID 0000-0001-9365-3702
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Renata L RihaDepartment of Sleep Medicine, The University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-8983-9985
Lorenz RischFaculty of Medical Sciences , Institute for Laboratory Medicine, Private University in the Principality of Liecht enstein, Vaduz, Liechtenstein.ORCID 0000-0003-2692-6699
Martin RischCentral Laboratory, Cantonal Hospital Graubünden, Chur, Switzerland.
Edward A Ruiz-NarvaezDepartment of Nutritional Sciences, University of Michigan, Ann Arbor, MI, USA.
Rodney J ScottSchool of Biomedical Sciences and Pharmacy, College of Health Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia.ORCID 0000-0001-7724-3404
Colleen M SitlaniCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0001-7656-7482
Jennifer A SmithSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Tamar SoferDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0001-8520-8860
Maris Teder-LavingEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Uwe VölkerDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Peter VollenweiderDepartment of Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Guanchao WangDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Ko Willems van DijkDepartment of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
Otis D WilsonBiomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626), Department of Veterans Affairs/ Nashville, TN, USA.
Rui XiaBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.
Jie YaoThe Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Kristin L YoungDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ruiyuan ZhangDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, US.
Xiaofeng ZhuDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Jennifer E BelowDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Carsten A BögerDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
David ConenPopulation Health Research Institute, Medicine, McMaster University, Hamilton, On, Canada.
Simon R CoxDepartment of Psychology, The University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-4036-3642
Marcus DörrDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-0933-2410
Ervin R FoxJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Nora FranceschiniDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0009-0001-8346-3662
Sina A GharibPulmonary, Critical Care and Sleep Medicine, Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2480-4367
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.ORCID 0000-0001-5696-0084
Sioban D HarlowDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Jiang HeDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, US.
Elizabeth G HollidaySchool of Medicine and Public Health, College of Health Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia.
Zoltan KutalikStatistical Genetics Group, Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Timo A LakkaInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Kuopio.ORCID 0000-0002-9199-2871
Deborah A LawlorMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Seunggeun LeeGraduate School of Data Science, Seoul National University, Seoul, South Korea.ORCID 0000-0002-8097-3878
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Changwei LiDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, US.ORCID 0000-0002-9203-304X
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Reedik MägiEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0002-2964-6011
Fumihiko MatsudaCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.
Brenda Wjh PenninxDepartment of Psychiatry, Amsterdam UMC/Vrije universiteit, Amsterdam, Netherlands.ORCID 0000-0001-7779-9672
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID 0000-0001-7191-1723
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Tim D SpectorDepartment of Twin Research, King's College London, London, UK.
Lynne E WagenknechtPublic Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0003-1422-2993
Alan B ZondermanLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
Kari E NorthDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-8903-0366
Myriam FornageBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.
Million Veteran Program
Adriana M HungBiomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626), Department of Veterans Affairs/ Nashville, TN, USA.
Alisa K ManningClinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
James GaudermanDivision of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-6626-9091
Han ChenHuman Genetics Center, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.
Patricia B MunroeClinical Pharmacology and Precision Medicine, Queen Mary University of London, London, UK.ORCID 0000-0002-4176-2947
Dabeeru C RaoCenter for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.
Diana van HeemstDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Lei den, Netherlands.
Susan RedlineDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Raymond NoordamDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Lei den, Netherlands.ORCID 0000-0001-7801-809X
Heming WangDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
University of North Carolina at Chapel Hill · USBrigham and Women's Hospital · USVanderbilt University Medical Center · USUniversity of Michigan · USNational Institutes of Health · USUCLA Medical Center · USUniversity of Washington · USJackson Memorial Hospital · USThe University of Texas Health Science Center at Houston · USTulane University · USUniversity Medical Center Groningen · NLSeoul National University · KRUniversitätsmedizin Greifswald · DEUniversity of Eastern Finland · FIUniversity of Edinburgh · GBUniversity of Lausanne · CHVA Tennessee Valley Healthcare System · USWake Forest University · USWashington University in St. Louis · USBroad Institute · US
Funding
Statistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI David V Conti · 2016 to 2026
$25.5MA Multi-Ancestry Study of Gene-Lifestyle Interactions and Multi-Omics in Cardiometabolic TraitsR01HL156991 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2021 to 2024
$8.8MA Multi-Ethnic Study of Gene-Lifestyle Interactions in Cardiovascular TraitsR01HL118305 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2014 to 2017
$8.3MGenetic Epidemiology of Sleep Apnea and Comorbidities in BiobanksR01HL153805 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CADE, BRIAN EDMAND · 2021 to 2025
$3.7MLeveraging ancestry to map kidney lociR01MD012765 · NIMHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2017 to 2021
$3.6MGenetics of kidney disease in diverse populationsR01DK117445 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2018 to 2022
$2.7MDissecting heterogeneity of excessive daytime sleepiness and impact on cardiovascular diseasesR01HL153814 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WANG, HEMING · 2021 to 2025
$2.0MGenetics of CKD and Hypertension-Risk Prediction and Drug Response in the MVPI01CX001897 · VA · VETERANS HEALTH ADMINISTRATION · PI Adriana Hung · 2020 to 2026
–Diabetic Complications and Genetic Variants in the Million Veterans ProgramI01BX005831 · VA · VETERANS HEALTH ADMINISTRATION · PI PHILLIPS, LAWRENCE S, SUN, YAN · 2022 to 2025
–BLRD VA I01 BX005831CSRD VA I01 CX001897NCI NIH HHS P01 CA196569NHLBI NIH HHS R01 HL118305NHLBI NIH HHS R01 HL153805NHLBI NIH HHS R01 HL153814NHLBI NIH HHS R01 HL156991NIDDK NIH HHS R01 DK117445NIMHD NIH HHS R01 MD012765
Abstract
Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discover 22 novel gene-sleep duration interaction loci for blood pressure, mapped to genes involved in neurological, thyroidal, bone metabolism, and hematopoietic pathways. Non-overlap between short sleep (12) and long sleep (10) interactions underscores the plausibility of distinct influences of both sleep duration extremes in cardiovascular health. With several of our loci reflecting specificity towards population background or sex, our discovery sheds light on the importance of embracing granularity when addressing heterogeneity entangled in gene-environment interactions, and in therapeutic design approaches for blood pressure management.
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.