Evidence map›Paper›PMID 38496528›Full record

ArticlebioRxiv : the preprint server for biology2024

Persistent Interruption in Parvalbumin Positive Inhibitory Interneurons: Biophysical and Mathematical Mechanisms.

Carol M Upchurch, Christopher J Knowlton, Simon Chamberland, Carmen C Canavier

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Carol M UpchurchDepartment of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, New Orleans, LA 70112.ORCID 0000-0002-8693-436X
Christopher J KnowltonDepartment of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, New Orleans, LA 70112.ORCID 0000-0002-5202-7374
Simon ChamberlandNYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY 10016, USA.ORCID 0000-0003-2061-4109
Carmen C CanavierDepartment of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, New Orleans, LA 70112.ORCID 0000-0003-4368-6906
Louisiana State University Health Sciences Center New Orleans · USNYU Langone Health · US

Funding

Synchronization in Noisy, Heterogeneous Excitatory/Inhibitory NetworksR01NS054281 · NINDS · LSU HEALTH SCIENCES CENTER · PI CANAVIER, CARMEN CASTRO · 2005 to 2022
$5.4M
CRCNS: Cholinergic contribution to hippocampal information processingR01MH115832 · NIMH · LSU HEALTH SCIENCES CENTER · PI CANAVIER, CARMEN CASTRO, GASPARINI, SONIA · 2017 to 2021
$1.8M
Synaptic and cellular mechanisms of neuronal synchronizationK99MH126157 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHAMBERLAND, SIMON · 2021 to 2022
$245k
NIMH NIH HHS K99 MH126157NIMH NIH HHS R01 MH115832NINDS NIH HHS R01 NS054281
6 · The paper itself

Abstract

Persistent activity in principal cells is a putative mechanism for maintaining memory traces during working memory. We recently demonstrated persistent interruption of firing in fast-spiking parvalbumin-expressing interneurons (PV-INs), a phenomenon which could serve as a substrate for persistent activity in principal cells through disinhibition lasting hundreds of milliseconds. Here, we find that hippocampal CA1 PV-INs exhibit type 2 excitability, like striatal and neocortical PV-INs. Modelling and mathematical analysis showed that the slowly inactivating potassium current K

Identifiers

PMID38496528
PMCPMC10942299
OpenAlexW4392548587

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.