Evidence map›Paper›PMID 38496509›Full record

ArticlebioRxiv : the preprint server for biology2024

Transcriptional plasticity of virulence genes provides malaria parasites with greater adaptive capacity for avoiding host immunity.

Francesca Florini, Joseph E Visone, Evi Hadjimichael, Shivali Malpotra, Christopher Nötzel, Björn F C Kafsack, Kirk W Deitsch

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Francesca FloriniDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.ORCID 0000-0003-2579-3820
Joseph E VisoneDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Evi HadjimichaelDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Shivali MalpotraDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Christopher NötzelDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Björn F C KafsackDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.ORCID 0000-0003-0089-1096
Kirk W DeitschDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Cornell University · US

Funding

Var gene regulation and antigenic variation in malariaR01AI052390 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEITSCH, KIRK W · 2002 to 2019
$6.6M
DNA repair and recombination within the var gene family of P. falciparumR01AI099327 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEITSCH, KIRK W · 2012 to 2016
$2.2M
A Molecular Switch Controlling Antigenic Variation in Malaria ParasitesF31AI164897 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI VISONE, JOSEPH EDWARD · 2022 to 2024
$143k
NIAID NIH HHS F31 AI164897NIAID NIH HHS R01 AI052390NIAID NIH HHS R01 AI099327
6 · The paper itself

Abstract

Chronic, asymptomatic malaria infections contribute substantially to disease transmission and likely represent the most significant impediment preventing malaria elimination and eradication.

Indexed as

antigenic variationgene expressionimmune evasionsingle cell RNAseqvar genes

Identifiers

PMID38496509
PMCPMC10942408
OpenAlexW4392633539

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.