Evidence map›Paper›PMID 38496495›Full record

ArticlebioRxiv : the preprint server for biology2024

Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK.

Caitlyn E Bowman, Michael D Neinast, Cholsoon Jang, Jiten Patel, Megan C Blair, Emily T Mirek, William O Jonsson, Qingwei Chu, Lauren Merlo, Laura Mandik-Nayak and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Caitlyn E BowmanCardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA.
Michael D NeinastDepartment of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Cholsoon JangDepartment of Biological Chemistry, University of California Irvine, Irvine, CA, USA.
Jiten PatelCardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA.
Megan C BlairCardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA.
Emily T MirekDepartment of Nutritional Sciences, Rutgers School of Environmental and Biological Sciences, New Brunswick, NJ, USA.
William O JonssonDepartment of Nutritional Sciences, Rutgers School of Environmental and Biological Sciences, New Brunswick, NJ, USA.
Qingwei ChuInstitute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lauren MerloLankenau Institute for Medical Research, Wynnewood, PA, USA.
Laura Mandik-NayakLankenau Institute for Medical Research, Wynnewood, PA, USA.
Tracy G AnthonyDepartment of Nutritional Sciences, Rutgers School of Environmental and Biological Sciences, New Brunswick, NJ, USA.
Joshua D RabinowitzDepartment of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Zolt AranyCardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA.
Cardiovascular Institute of the South · USRutgers, The State University of New Jersey · USLankenau Institute for Medical Research · USPrinceton University · USUniversity of California, Irvine · USUniversity of Pennsylvania · USWilliams College · US

Funding

VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Patrick Seale · 1986 to 2026
$48.3M
Training Program in Cardiovascular Biology and MedicineT32HL007843 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI THOMAS P. CAPPOLA, Sharlene M Day · 1996 to 2026
$11.0M
Homeostatic Responses to Amino Acid InsufficiencyR01DK109714 · NIDDK · RUTGERS, THE STATE UNIV OF N.J. · PI ANTHONY, TRACY G., WEK, RONALD C · 2016 to 2024
$5.4M
Keeping fat out of muscle - Role of Branched Amino AcidsAmino Acids in Insulin ResistanceR01DK114103 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Zoltan P Arany · 2018 to 2026
$4.5M
Branched chain amino acids in pancreatic carcinogenesisR01CA248315 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Zoltan P Arany, Kathryn Elaine Wellen · 2020 to 2026
$2.8M
Post-doctoral Training Program in Cancer Metabolism and Tumor-host InteractionsT32CA257957 · NCI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI KANG, YIBIN, ZONG, WEI-XING · 2021 to 2025
$1.2M
NCI NIH HHS R01 CA248315NCI NIH HHS T32 CA257957NHLBI NIH HHS T32 HL007843NIDDK NIH HHS P30 DK019525NIDDK NIH HHS R01 DK109714NIDDK NIH HHS R01 DK114103
6 · The paper itself

Abstract

The activation of branched chain amino acid (BCAA) catabolism has garnered interest as a potential therapeutic approach to improve insulin sensitivity, enhance recovery from heart failure, and blunt tumor growth. Evidence for this interest relies in part on BT2, a small molecule that promotes BCAA oxidation and is protective in mouse models of these pathologies. BT2 and other analogs allosterically inhibit branched chain ketoacid dehydrogenase kinase (BCKDK) to promote BCAA oxidation, which is presumed to underlie the salutary effects of BT2. Potential "off-target" effects of BT2 have not been considered, however. We therefore tested for metabolic off-target effects of BT2 in

Identifiers

PMID38496495
PMCPMC10942310
OpenAlexW4392655303

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.