ArticlebioRxiv : the preprint server for biology2024
N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine.
Chuchu Wang, Chunyu Zhao, Xiao Hu, Jiali Qiang, Zhenying Liu, Jinge Gu, Shengnan Zhang, Dan Li, Yaoyang Zhang, Jacqueline Burré and 2 more
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
12 authors at 4 institutions in 2 countries.
Chuchu WangInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Chunyu ZhaoInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.ORCID 0000-0003-0168-2130 Xiao HuDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Jiali QiangInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Zhenying LiuInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Jinge GuInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Shengnan ZhangInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Dan LiBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, China.ORCID 0000-0002-1609-1539 Yaoyang ZhangInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Jacqueline BurréBrain and Mind Research Institute & Appel Institute for Alzheimer's Disease Research, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0001-8968-248X Jiajie DiaoDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.ORCID 0000-0003-4288-3203 Cong LiuInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.ORCID 0000-0003-3425-6672 Chinese Academy of Sciences · CNUniversity of Cincinnati Medical Center · USCornell University · USShanghai Jiao Tong University · CN
Funding
The impact of synaptic vesicle-binding of alpha-synuclein on neuron function and neuropathologyR01NS113960 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BURRE, JACQUELINE · 2020 to 2024
$2.4MThe Impact of Beta- and Gamma-Synucleins on Alpha-Synuclein's Synaptic FunctionRF1NS126342 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BURRE, JACQUELINE, SHARMA, MANU · 2022 to 2023
$2.3MThe role of VAMP2 in alpha-synuclein function and pathologyR01NS121077 · NINDS · UNIVERSITY OF CINCINNATI · PI BURRE, JACQUELINE, DIAO, JIAJIE · 2021 to 2025
$1.9MMolecular mechanisms of Munc18-1 linked infantile seizure disorders and rational rescue strategiesR01NS102181 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BURRE, JACQUELINE · 2017 to 2021
$1.8MSynaptic vesicle changes in synucleinopathiesR21NS127939 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BURRE, JACQUELINE · 2022 to 2022
$464kNINDS NIH HHS R01 NS102181NINDS NIH HHS R01 NS113960NINDS NIH HHS R01 NS121077NINDS NIH HHS R21 NS127939NINDS NIH HHS RF1 NS126342
6 · The paper itselfAbstract
Post-translational modifications (PTMs) of α-synuclein (α-syn) such as acetylation and phosphorylation play important yet distinct roles in regulating α-syn conformation, membrane binding, and amyloid aggregation. However, how PTMs regulate α-syn function in presynaptic terminals remains unclear. Previously, we reported that α-syn clusters synaptic vesicles (SV)
Indexed as
N-acetylationvesicle clusteringα-synuclein
Identifiers
PMID38496494
PMCPMC10942363
OpenAlexW4392586962
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