ArticlebioRxiv : the preprint server for biology2024
Strain heterogeneity in a non-pathogenic fungus highlights factors contributing to virulence.
David C Rinker, Thomas J C Sauters, Karin Steffen, Adiyantara Gumilang, Huzefa A Raja, Manuel Rangel-Grimaldo, Camila Figueiredo Pinzan, Patrícia Alves de Castro, Thaila Fernanda Dos Reis, Endrews Delbaje and 4 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
14 authors.
David C RinkerDepartment of Biological Sciences and Evolutionary Studies Initiative, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0001-5894-7633 Thomas J C SautersDepartment of Biological Sciences and Evolutionary Studies Initiative, Vanderbilt University, Nashville, Tennessee, USA.
Karin SteffenDepartment of Biological Sciences and Evolutionary Studies Initiative, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0003-0499-1430 Adiyantara GumilangDepartment of Biological Sciences and Evolutionary Studies Initiative, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0002-8887-9763 Huzefa A RajaDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina, USA.ORCID 0000-0002-0824-9463 Manuel Rangel-GrimaldoDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina, USA.
Camila Figueiredo PinzanFaculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
Patrícia Alves de CastroFaculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
Thaila Fernanda Dos ReisFaculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
Endrews DelbajeFaculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-0313-9046 Jos HoubrakenFood and Indoor Mycology, Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.ORCID 0000-0003-4893-4438 Gustavo H GoldmanFaculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-2986-350X Nicholas H OberliesDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina, USA.
Antonis RokasDepartment of Biological Sciences and Evolutionary Studies Initiative, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0002-7248-6551 Funding
Deciphering the phenotypic and genomic traits that underlie the evolution of pathogenicity differences among Aspergillus fumigatus and its close relativesR01AI153356 · NIAID · VANDERBILT UNIVERSITY · PI Antonis Rokas · 2022 to 2026
$3.5MNIAID NIH HHS R01 AI153356
6 · The paper itselfAbstract
Fungal pathogens exhibit extensive strain heterogeneity, including variation in virulence. Whether closely related non-pathogenic species also exhibit strain heterogeneity remains unknown. Here, we comprehensively characterized the pathogenic potentials (i.e., the ability to cause morbidity and mortality) of 16 diverse strains of
Indexed as
comparative genomicsevolution of virulencefungal pathogenicitygliotoxinsecondary metabolismspecialized metabolismvirulence factor
Identifiers
PMID38496489
PMCPMC10942418
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