Evidence map›Paper›PMID 38496457›Full record

ArticlebioRxiv : the preprint server for biology2024

A novel protein Moat prevents ectopic epithelial folding by limiting Bazooka/Par3-dependent adherens junctions.

Lingkun Gu, Rolin Sauceda, Jasneet Brar, Ferdos Fessahaye, Minsang Joo, Joan Lee, Jacqueline Nguyan, Marissa Teng, Mo Weng

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lingkun GuSchool of Life Sciences, University of Nevada, Las Vegas, NV 89154, USA.ORCID 0000-0002-6364-0094
Rolin SaucedaSchool of Life Sciences, University of Nevada, Las Vegas, NV 89154, USA.ORCID 0000-0002-3039-7649
Jasneet BrarSchool of Life Sciences, University of Nevada, Las Vegas, NV 89154, USA.
Ferdos FessahayeSchool of Life Sciences, University of Nevada, Las Vegas, NV 89154, USA.ORCID 0000-0002-8163-312X
Minsang JooSchool of Life Sciences, University of Nevada, Las Vegas, NV 89154, USA.
Joan LeeDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Jacqueline NguyanSchool of Life Sciences, University of Nevada, Las Vegas, NV 89154, USA.
Marissa TengSchool of Life Sciences, University of Nevada, Las Vegas, NV 89154, USA.
Mo WengSchool of Life Sciences, University of Nevada, Las Vegas, NV 89154, USA.ORCID 0000-0001-9144-8772
University of Nevada, Las Vegas · USPrinceton University · US

Funding

Mechanosensitive remodeling of adherens junctions during snail-driven EMTR00HD088764 · NICHD · UNIVERSITY OF NEVADA LAS VEGAS · PI WENG, MO · 2018 to 2020
$742k
Mechanosensitive remodeling of adherens junctions during snail-driven EMTK99HD088764 · NICHD · PRINCETON UNIVERSITY · PI WENG, MO · 2016 to 2017
$179k
NICHD NIH HHS K99 HD088764NICHD NIH HHS R00 HD088764
6 · The paper itself

Abstract

Cortical myosin contraction and cell adhesion work together to promote tissue shape changes, but how they are modulated to achieve diverse morphogenetic outcomes remains unclear. Epithelial folding occurs via apical constriction, mediated by apical accumulation of contractile myosin engaged with adherens junctions, as in Drosophila ventral furrow formation. While levels of contractile myosin correlate with apical constriction, whether levels of adherens junctions modulate apical constriction is unknown. We identified a novel Drosophila gene

Indexed as

Adherens junctionsApical constrictionBazooka/Par3morphogenesisMyosinPatterning

Identifiers

PMID38496457
PMCPMC10942281
OpenAlexW4392631234

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.