ArticlebioRxiv : the preprint server for biology2024
A Spatial Multi-Modal Dissection of Host-Microbiome Interactions within the Colitis Tissue Microenvironment.
Bokai Zhu, Yunhao Bai, Yao Yu Yeo, Xiaowei Lu, Xavier Rovira-Clavé, Han Chen, Jason Yeung, Georg K Gerber, Mike Angelo, Alex K Shalek and 2 more
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 4 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors at 6 institutions in 2 countries.
Yunhao BaiBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Yao Yu YeoCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Xiaowei LuMass Spectrometry Core Facility, Stanford University, Stanford, CA, United States.
Xavier Rovira-ClavéDepartment of Microbiology and Immunology, Stanford University, Stanford, CA, United States.
Han ChenDepartment of Microbiology and Immunology, Stanford University, Stanford, CA, United States.
Jason YeungCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Georg K GerberDivision of Computational Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-9149-5509 Alex K ShalekRagon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
Garry P NolanDepartment of Pathology, Stanford University, Stanford, CA, United States.
Broad Institute · USStanford University · USBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · USInstitute for Bioengineering of Catalonia · ESUniversity of California San Francisco Medical Center · US
Funding
Cancer Immune Monitoring and Analysis CenterU24CA224331 · NCI · DANA-FARBER CANCER INST · PI FRANK S HODI, Catherine Ju-Ying Wu · 2017 to 2026
$18.4MNHP CoreP01AI177687 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Boris Dominik Juelg · 2023 to 2026
$7.4MSingle-Cell Analysis of the HIV/SIV ReservoirR01AI149670 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BAROUCH, DAN H., SHALEK, ALEX K · 2020 to 2024
$4.6MDefining Mechanisms of Viral Persistence in Situ at the Single-Cell LevelR01AI149672 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI ESTES, JACOB D · 2020 to 2024
$4.0MSpatial-Temporal Dissection of Stratified Host Tissue Responses to Severe acute respiratory syndrome-related coronaviruses in situ to Understand Intra-host PathogenesisDP2AI171139 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Sizun Jiang · 2022 to 2026
$2.3MProbabilistic deep learning models and integrated biological experiments for analyzing dynamic and heterogeneous microbiomesR35GM149270 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Georg Kurt Gerber · 2023 to 2026
$1.8MBayesian Machine Learning Tools for Analyzing Microbiome DynamicsR01GM130777 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI GERBER, GEORG KURT · 2018 to 2022
$1.6MNCI NIH HHS U24 CA224331NIAID NIH HHS DP2 AI171139NIAID NIH HHS P01 AI177687NIAID NIH HHS R01 AI149670NIAID NIH HHS R01 AI149672NIGMS NIH HHS R01 GM130777NIGMS NIH HHS R35 GM149270
6 · The paper itselfAbstract
The intricate and dynamic interactions between the host immune system and its microbiome constituents undergo dynamic shifts in response to perturbations to the intestinal tissue environment. Our ability to study these events on the systems level is significantly limited by
Indexed as
GlycomicsGut MicrobiotaMultiplexed imagingSpatial ProteomicsSpatial TranscriptomicsSystems Immunology
Identifiers
PMID38496402
PMCPMC10942342
OpenAlexW4392507531
What OpenQuestion holds
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LicenceCC BY-NC
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