Evidence map›Paper›PMID 38496398›Full record

ArticlebioRxiv : the preprint server for biology2024

Microglia Depletion leads to Increased Susceptibility to Ocular Hypertension-Dependent Glaucoma.

Cory A Diemler, Michael MacLean, Sarah E Heuer, Amanda A Hewes, Olivia J Marola, Richard T Libby, Gareth R Howell

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Cory A DiemlerThe Jackson Laboratory, Bar Harbor, ME.
Michael MacLeanThe Jackson Laboratory, Bar Harbor, ME.
Sarah E HeuerThe Jackson Laboratory, Bar Harbor, ME.
Amanda A HewesThe Jackson Laboratory, Bar Harbor, ME.
Olivia J MarolaThe Jackson Laboratory, Bar Harbor, ME.
Richard T LibbyFlaum Eye Institute, University of Rochester Medical Center, Rochester, NY.
Gareth R HowellThe Jackson Laboratory, Bar Harbor, ME.ORCID 0000-0003-0565-6474
Jackson Laboratory · USUniversity of Rochester Medical Center · USTufts University · US

Funding

Dissecting the complex role of microglia states in glaucomaR01EY035093 · NEI · UNIVERSITY OF ROCHESTER · PI Gareth R Howell, Richard T Libby · 2023 to 2026
$2.6M
NEI NIH HHS R01 EY035093
6 · The paper itself

Abstract

In recent years, microglia have been highlighted for playing integral roles in neurodegenerative diseases, like glaucoma. To better understand the role of microglia during chronic ocular hypertension, we depleted microglia from aged (9-12 months old) DBA/2J (D2) mice, which exhibit age-related increases in intraocular pressure, using a dietary CSF1R antagonist, PLX5622. Retinal ganglion cell (RGC) somas were counted, and optic nerve cross-sections stained and assessed for glaucomatous damage. Sustained administration of dietary PLX5622 significantly reduced the numbers of retinal microglia. Dietary PLX5622 did not lead to changes in intraocular pressure in D2 or normotensive DBA/2J-

Identifiers

PMID38496398
PMCPMC10942367
OpenAlexW4392634287

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.