Evidence map›Paper›PMID 38496317›Full record

ArticleFrontiers in aging2024

How are APOE4, changes in body weight, and longevity related? Insights from a causal mediation analysis.

Rachel Holmes, Hongzhe Duan, Olivia Bagley, Deqing Wu, Yury Loika, Alexander Kulminski, Anatoliy Yashin, Konstantin Arbeev, Svetlana Ukraintseva

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
5.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Rachel HolmesBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, United States.
Hongzhe DuanBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, United States.
Olivia BagleyBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, United States.
Deqing WuBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, United States.
Yury LoikaBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, United States.
Alexander KulminskiBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, United States.
Anatoliy YashinBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, United States.
Konstantin ArbeevBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, United States.
Svetlana UkraintsevaBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, United States.
Social Science Research Council · USDuke University · US

Funding

Understanding Alzheimer's Disease in the Context of the AgingR01AG062623 · NIA · DUKE UNIVERSITY · PI OUKRAINTSEVA, SVETLANA V. · 2019 to 2023
$3.6M
Genetics of changes in population pyramids: Implications for health forecasting with a focus on Alzheimer's Disease and related dementiasRF1AG046860 · NIA · DUKE UNIVERSITY · PI YASHIN, ANATOLIY I · 2019 to 2019
$3.1M
Dissecting genetic and non-genetic heterogeneity in predisposition to Alzheimer's disease and vascular traits in pleiotropic contextR01AG070488 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M, OUKRAINTSEVA, SVETLANA V. · 2020 to 2024
$2.8M
Genetics of aging, health and longevity: focus on regulatory mechanisms and functional variants connecting aging and Alzheimer's diseaseR01AG070487 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M, OUKRAINTSEVA, SVETLANA V. · 2020 to 2023
$2.0M
NIA NIH HHS R01 AG062623NIA NIH HHS R01 AG070487NIA NIH HHS R01 AG070488NIA NIH HHS RF1 AG046860
6 · The paper itself

Abstract

The ε4 allele of the APOE gene (

Indexed as

agingApoE4causal inferencelongevitymediationweight

Identifiers

PMID38496317
PMCPMC10941013
OpenAlexW4392354370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.