Evidence map›Paper›PMID 38495956›Full record

ArticleBrain, behavior, & immunity - health2024

Neurofilament light-chain (NfL) and 18 kDa translocator protein in early psychosis and its putative high-risk.

Kankana Nisha Aji, Giulia Cisbani, Ana Weidenauer, Alex Koppel, Sina Hafizi, Tania Da Silva, Michael Kiang, Pablo M Rusjan, Richard P Bazinet, Romina Mizrahi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kankana Nisha AjiDepartment of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada.
Giulia CisbaniDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Ana WeidenauerDivision of General Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Alex KoppelDepartment of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada.
Sina HafiziResearch Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Tania Da SilvaResearch Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Michael KiangResearch Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Pablo M RusjanDouglas Research Centre, Clinical and Translational Sciences Lab, Montreal, Quebec, Canada.
Richard P BazinetDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Romina MizrahiDouglas Research Centre, Clinical and Translational Sciences Lab, Montreal, Quebec, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence of elevated peripheral Neurofilament light-chain (NfL) as a biomarker of neuronal injury can be utilized to reveal nonspecific axonal damage, which could reflect altered neuroimmune function. To date, only a few studies have investigated NfL as a fluid biomarker in schizophrenia primarily, though none in its putative prodrome (Clinical High-Risk, CHR) or in untreated first-episode psychosis (FEP). Further, it is unknown whether peripheral NfL is associated with 18 kDa translocator protein (TSPO), a validated neuroimmune marker. In this secondary study, we investigated for the first time (1) serum NfL in early stages of psychosis including CHR and FEP as compared to healthy controls, and (2) examined its association with brain TSPO, using [

Indexed as

Clinical high-riskFirst-episode psychosisNeurofilament light-chainNeuroinflammationPETTSPO

Identifiers

PMID38495956
PMCPMC10940889

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.