Evidence map›Paper›PMID 38495887›Full record

SynthesisFrontiers in immunology2024

Level of IL-6, TNF, and IL-1β and age-related diseases: a systematic review and meta-analysis.

Anna Tylutka, Łukasz Walas, Agnieszka Zembron-Lacny

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 160 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
160citing papers in PubMed, 3 pooled it
59.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

160 citing papers in PubMed, 3 syntheses or guidelines pooled it, 183 citations in OpenAlex.

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  19. The immunology behind inflammaging-causes, sources, and mechanisms.The Journal of allergy and clinical immunology · 2026
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100 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Anna TylutkaDepartment of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, Zielona Gora, Poland.
Łukasz WalasInstitute of Dendrology, Polish Academy of Sciences, Kórnik, Poland.
Agnieszka Zembron-LacnyDepartment of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, Zielona Gora, Poland.
University of Zielona Góra · PLInstitute of Dendrology · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Chronic low-grade inflammation is an important aspect of morbidity and mortality in older adults. The level of circulating pro-inflammatory cytokines (interleukin (IL)-6, tumor necrosis factor (TNF) or IL-1β) is a risk factor in cardiovascular and neurodegenerative diseases and is also associated with sarcopenia and frailties. The objective of this study was to assess each cytokine: IL-6, TNF, and IL-1β separately in the elderly with comorbidities against controls without diseases according to the data published in the available literature. Methods: The electronic bibliographic PubMed database was systematically searched to select all the relevant studies published up to July 2023. The total number of the subjects involved in the meta-analysis included patients with diseases ( Results: The overall concentration of IL-6 was found to be higher in patients with diseases compared to controls and the difference was statistically significant, with a Discussion: IL-6, unlike TNF and IL-1β, could be a useful and convenient marker of peripheral inflammation in older adults with various comorbidities.

Indexed as

CytokinesInterleukin-6AgedAgingHumansInflammationInterleukin-1betaTumor Necrosis Factor-alphaCytokinesIL1B protein, humanIL6 protein, humanInterleukin-1betaInterleukin-6Tumor Necrosis Factor-alphacomorbiditiesimmunosenescenceinterleukin 1βinterleukin 6tumor necrosis factor

Identifiers

PMID38495887
PMCPMC10943692
OpenAlexW4392353613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.