Evidence map›Paper›PMID 38495823›Full record

ArticleiScience2024

Language model and its interpretability in biomedicine: A scoping review.

Daoming Lyu, Xingbo Wang, Yong Chen, Fei Wang

Abstract readScoping Review
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daoming LyuInstitute of Artificial Intelligence for Digital Health, Weill Cornell Medicine, New York, NY, USA.
Xingbo WangInstitute of Artificial Intelligence for Digital Health, Weill Cornell Medicine, New York, NY, USA.
Yong ChenDepartment of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Fei WangInstitute of Artificial Intelligence for Digital Health, Weill Cornell Medicine, New York, NY, USA.

Funding

TREM2 Genotype-Informed Drug Repurposing and Combination Therapy Design for Alzheimer’s DiseaseR01AG076448 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI Feixiong Cheng, Li Gan · 2022 to 2026
$4.0M
Computational Drug Repurposing for AD/ADRD with Integrative Analysis of Real World Data and Biomedical KnowledgeR01AG076234 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Jiang Bian, Fei Wang · 2022 to 2026
$3.8M
Developing Suicide Risk Algorithms for Diverse Clinical Settings using Data FusionR01MH124740 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI ASELTINE, ROBERT H, CHEN, KUN · 2020 to 2023
$3.2M
Eligibility criteria design for Alzheimer's trials with real-world data and explainable AIR01AG080991 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Jiang Bian, Fei Wang · 2023 to 2026
$3.1M
Disparities of Alzheimer's disease progression in Sexual Minority IndividualsR01AG080624 · NIA · UNIVERSITY OF FLORIDA · PI Jiang Bian, Yi Guo · 2023 to 2026
$3.1M
Identification of Mild Cognitive Impairment using Machine Learning from Language and Behavior MarkersRF1AG072449 · NIA · MICHIGAN STATE UNIVERSITY · PI DODGE, HIROKO HAYAMA, WANG, FEI · 2021 to 2023
$2.6M
NIA NIH HHS R01 AG076234NIA NIH HHS R01 AG076448NIA NIH HHS R01 AG080624NIA NIH HHS R01 AG080991NIA NIH HHS RF1 AG072449NIMH NIH HHS R01 MH124740
6 · The paper itself

Abstract

With advancements in large language models, artificial intelligence (AI) is undergoing a paradigm shift where AI models can be repurposed with minimal effort across various downstream tasks. This provides great promise in learning generally useful representations from biomedical corpora, at scale, which would empower AI solutions in healthcare and biomedical research. Nonetheless, our understanding of how they work, when they fail, and what they are capable of remains underexplored due to their emergent properties. Consequently, there is a need to comprehensively examine the use of language models in biomedicine. This review aims to summarize existing studies of language models in biomedicine and identify topics ripe for future research, along with the technical and analytical challenges w.r.t. interpretability. We expect this review to help researchers and practitioners better understand the landscape of language models in biomedicine and what methods are available to enhance the interpretability of their models.

Indexed as

Computer scienceHealth sciencesNatural sciences

Identifiers

PMID38495823
PMCPMC10940999

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.