ArticleiScience2024
Social isolation and loneliness with risk of cardiometabolic multimorbidity: A prospective cohort study from UK Biobank.
Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 9 citations in OpenAlex.
- Sensory impairment, activities of daily living, and multimorbidity in middle-aged and older adults: evidence from the China health and retirement longitudinal study.BMC public health · 2026Article
- Loneliness, Chronic Conditions, and Healthcare Engagement in Japan: A Nationwide Cross-Sectional Study.JMA journal · 2026Article
- Loneliness, Social Isolation, and Chronic Disease Outcomes in Adults: A Systematic Review.Cureus · 2026Review
- Loneliness, traditional risk factor control, genetic predisposition, and development of musculoskeletal disorders.Rheumatology (Oxford, England) · 2026Article
- The impact of sensory impairment on cardiometabolic multimorbidity in middle-aged and older adults: the mediating role of depressive symptoms.European journal of medical research · 2025Article
- Personal, social, and natural co-exposure pattern and plasma proteins in cardiometabolic diseases.Nature communications · 2025Article
- Observational
- Linking cardiometabolic multimorbidity to depressive symptoms in the oldest-old: results from a cross-sectional study in Germany.BMC public health · 2025Article
- Loneliness, Social Isolation, and Digital Health Literacy Among Older Women Living Alone in South Korea During the COVID-19 Pandemic.Psychiatry investigation · 2025Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pandemic of the coronavirus disease 2019 resulted in an increased prevalence of social isolation and loneliness. Cox proportional hazards regression was used to test the association between social isolation/loneliness, multiple cardiometabolic diseases (CMDs) and cardiometabolic multimorbidity (CMM). In the multivariable adjusted models, compared with the least isolated, the most isolated had independently associated with CMD (HR 1.07, 95% CI 1.03 to 1.11) and CMM (HR 1.24, 95% CI 1.12 to 1.36) in stage I, and CMM in stage II (HR 1.14, 95% CI 1.05 to 1.23). Compared with those with the least loneliness, those who with most loneliness had about 20% increased risk of CMD and 29% increased risk of CMM in stage I. Those with the most loneliness were also significantly associated with increased CMM risk (HR 1.30, 95% CI 1.19 to 1.42) in stage II. This study revealed the associations of social isolation/loneliness with CMD and CMM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.