Evidence map›Paper›PMID 38495773›Full record

ArticleOpen forum infectious diseases2024

Resurgence of Respiratory Syncytial Virus in the Summer of 2021 in Denmark-a Large out-of-season Epidemic Affecting Older Children.

Frederikke Kristensen Lomholt, Hanne-Dorthe Emborg, Sarah Kristine Nørgaard, Jens Nielsen, Charlotte Munkstrup, Karina Lauenborg Møller, Jesper Schak Krog, Ramona Trebbien, Lasse Skafte Vestergaard

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Evaluation of the Automated and Early Detection of Seasonal Epidemic Onset and Burden Levels (AEDSEO) method for respiratory surveillance using data from 21 European countries.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
    Article
  2. Article
  3. Review
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  5. Article
  6. Primary care sentinel surveillance of influenza-like illness and laboratory detections of respiratory viral infections in Denmark, week 40 2021 to week 39 2023.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
  7. Surveillance of severe acute respiratory infections using ICD-10 diagnosis codes and national electronic health records, Denmark, 2022 to 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
  8. Article
  9. Observational
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  11. Review
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  15. Excess mortality in Europe coincides with peaks of COVID-19, influenza and respiratory syncytial virus (RSV), November 2023 to February 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Frederikke Kristensen LomholtDepartment of Infections Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark.ORCID https://orcid.org/0009-0007-5284-2073
Hanne-Dorthe EmborgDepartment of Infections Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-8062-0864
Sarah Kristine NørgaardDepartment of Infections Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark.
Jens NielsenDepartment of Infections Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-6477-2219
Charlotte MunkstrupDepartment of Infections Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-7750-6291
Karina Lauenborg MøllerDivision of Infectious Disease Preparedness, Statens Serum Institut, Copenhagen, Denmark.
Jesper Schak KrogDepartment of Virus and Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-1727-9904
Ramona TrebbienDepartment of Virus and Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-2352-5726
Lasse Skafte VestergaardDepartment of Infections Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: When coronavirus disease 2019 (COVID-19) restrictions were lifted in Denmark in the spring of 2021, a surge in respiratory syncytial virus (RSV) cases followed, causing a large out-of-season epidemic. This study aims to investigate the summer epidemic compared with 3 typical pre-COVID-19 RSV winter seasons using Danish registers to identify RSV cases, RSV-related admissions, and use of intensive care treatment. Methods: Incidence rates (IR) per 1000 person-years for RSV cases, RSV-related admissions, and intensive care treatment were calculated with 95% confidence interval (CI) for each season, stratified by age groups and incidence rate ratios (IRR) with 95% CI were calculated to compare the summer epidemic with the winter season for 2019-2020. Results: In the summer epidemic, the IR of RSV cases and admissions exceeded previous winter seasons for all age groups. The highest increases in IRs were seen among children aged 2 to 3 years and 4 to 5 years. The IRR of cases were 4.6 (95% CI, 4.1-5.2) and 3.3 (2.6-4.2) and the IRR of admissions were 3.3 (2.7-4.2) and 3.8 (2.3-6.5) in the 2 age groups, respectively, when compared with the winter season 2019-2020. Conclusions: Likely because of immunity debt following COVID-19 restrictions, the summer epidemic was significantly larger than previous winter seasons, most markedly among children aged 2 to 3 and 4 to 5 years but had a similar disease severity spectrum.

Indexed as

epidemiologyout-of-season epidemicregister-based studyrespiratory syncytial virus (RSV)surveillance

Identifiers

PMID38495773
PMCPMC10941316

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.