Evidence map›Paper›PMID 38495593›Full record

ArticleChina CDC weekly2024

Genetic Insights into Glycine's Protective Role Against CAD - European and East Asia, 2015 and 2020.

Jiaying Yu, Zhuolin Zhu, Ting Wang, Yuanhao Wei, Lianjie Huang, Qianru Zhang, Yuting Zhang, Yiran Wang, Guiyou Liu, Xiang Shu and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in China CDC weekly, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Jiaying YuDepartment of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin City, Heilongjiang Province, China.
Zhuolin ZhuSongyang County Center for Disease Prevention and Control, Songyang City, Zhejiang Province China.
Ting WangDepartment of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin City, Heilongjiang Province, China.
Yuanhao WeiDepartment of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin City, Heilongjiang Province, China.
Lianjie HuangDepartment of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin City, Heilongjiang Province, China.
Qianru ZhangDepartment of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin City, Heilongjiang Province, China.
Yuting ZhangDepartment of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin City, Heilongjiang Province, China.
Yiran WangDepartment of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin City, Heilongjiang Province, China.
Guiyou LiuDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Xiang ShuDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
Rennan FengDepartment of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin City, Heilongjiang Province, China.
Harbin Medical University · CNCenter for Disease Control · TWMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Introduction: The purpose of this study is to examine the potential causal relationship between levels of circulating glycine and coronary artery disease (CAD) using a two-step Mendelian randomization (MR) analysis. Methods: We analyzed data from genome-wide association studies (GWAS) conducted on European and East Asian populations. To assess the causal effects of circulating glycine levels on the risk of CAD. We used the inverse-variance weighting (IVW), weighted median (WM), MR-Egger, and Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO) methods. Furthermore, we conducted mediation analysis to investigate the contribution of blood pressure and other cardiovascular disease-related traits. Results: The two-step Mendelian randomization analysis revealed that higher levels of glycine in the blood were associated with a reduced risk of CAD in Europeans [odds ratio ( Discussion: Our results contribute to the current knowledge regarding the involvement of glycine in the progression of CAD, and provide valuable methodological insights for the prevention and treatment of this condition.

Indexed as

Circulating glycinecoronary artery diseaseMendeliansystolic blood pressure

Identifiers

PMID38495593
PMCPMC10937183
OpenAlexW4392401234

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.