Evidence map›Paper›PMID 38495529›Full record

ArticleAdvanced materials technologies2023

Programmable Control of Nanoliter Droplet Arrays using Membrane Displacement Traps.

Jason Harriot, Michael Yeh, Mani Pabba, Don L DeVoe

Abstract read
In one paragraph

Article in Advanced materials technologies, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jason HarriotDepartment of Mechanical Engineering, University of Maryland, College Park, MD 20742.
Michael YehDepartment of Mechanical Engineering, University of Maryland, College Park, MD 20742.
Mani PabbaDepartment of Computer Science, University of Maryland, College Park, MD 20742.
Don L DeVoeDepartment of Mechanical Engineering, University of Maryland, College Park, MD 20742.

Funding

A rapid, automated system for bacteria profiling of intra-abdominal infectionsR01AI153564 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI DEVOE, DON L, WHITE, IAN M · 2021 to 2025
$2.7M
Enabling exosome biomarker development via digitized single vesicle analysisR01GM130923 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI DEVOE, DON L, WHITE, IAN M · 2019 to 2022
$1.7M
Elucidating Airborne SARS-CoV-2 Infectivity at Single Aerosol ResolutionR21AI161501 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI DEVOE, DON L, MILTON, DONALD KIRBY · 2022 to 2022
$414k
NIAID NIH HHS R01 AI153564NIAID NIH HHS R21 AI161501NIGMS NIH HHS R01 GM130923
6 · The paper itself

Abstract

A unique droplet microfluidic technology enabling programmable deterministic control over complex droplet operations is presented. The platform provides software control over user-defined combinations of droplet generation, capture, ejection, sorting, splitting, and merging sequences to enable the design of flexible assays employing nanoliter-scale fluid volumes. The system integrates a computer vision system with an array of membrane displacement traps capable of performing selected unit operations with automated feedback control. Sequences of individual droplet handling steps are defined through a robust Python-based scripting language. Bidirectional flow control within the microfluidic chips is provided using an H-bridge channel topology, allowing droplets to be transported to arbitrary trap locations within the array for increased operational flexibility. By enabling automated software control over all droplet operations, the system significantly expands the potential of droplet microfluidics for diverse biological and biochemical applications by combining the functionality of robotic liquid handling with the advantages of droplet-based fluid manipulation.

Identifiers

PMID38495529
PMCPMC10939115

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.