ReviewEClinicalMedicine2024
Population-level interventions for the primary prevention of dementia: a complex evidence review.
Review in EClinicalMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- From advice to agency: making brain health actionable and equitable for middle-aged adults with mild neurocognitive disorder.The journal of prevention of Alzheimer's disease · 2026Article
- Economic evaluation of population-level dementia prevention strategies in China: informing policy and public health action.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- A Global Burden Perspective on Obstructive Sleep Apnea, Hearing Loss, and Early-Onset Cognitive Decline.Neurology international · 2026Review
- The principles of Population-Level Approaches to Dementia Risk Reduction (PLADRR).PLoS medicine · 2026Article
- Involving Societal Stakeholders in Dementia Risk Reduction: An Explorative Study.Health expectations : an international journal of public participation in health care and health policy · 2026Article
- The Nottingham consensus on dementia risk reduction policy: recommendations from a modified Delphi process.Nature reviews. Neurology · 2026Review
- The Population Neuroscience-Dementia Syndemics Framework to better understand global sex and gender-based risk in low- and middle-income countries.Nature aging · 2026Review
- The potential for dementia prevention in Japan: a population attributable fraction calculation for 14 modifiable risk factors and estimates of the impact of risk factor reductions.The Lancet regional health. Western Pacific · 2026Article
- Article
- Prevalence and co-occurrence of dementia risk factors in Denmark: A nationwide study.The journal of prevention of Alzheimer's disease · 2025Article
- Impact of adverse childhood experiences, post-traumatic stress disorder, dissociative disorders, and depression on dementia risk: a prospective analysis of associations and mediation in the UK Biobank cohort.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Translating lifestyle interventions for optimal brain health in Africa.Nature reviews. Neurology · 2025Review
- Estimating the impact of risk factor reduction on dementia prevalence in New Zealand.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Socio-ecological barriers to behavior change-oriented dementia prevention: a qualitative study of healthcare professionals' perspectives.Aging & mental health · 2025Observational
- Evolution of strategic framework of policies related to dementia care and prevention in China from 2000 to 2024.The Lancet regional health. Western Pacific · 2025Article
- Association between sarcopenic obesity and dementia in the Chinese elderly using different definitions of obesity: evidence from the CHARLS.Frontiers in aging neuroscience · 2025Article
- Scoping review of dementia primary prevention policies in England: do they balance reach and agency?BMJ public health · 2025Article
- Associations of socioeconomic status and healthy lifestyle with incident dementia and cognitive decline: two prospective cohort studies.EClinicalMedicine · 2024Article
- Thinking outside the brain: Gut microbiome influence on innate immunity within neurodegenerative disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- How many future dementia cases would be missed by a high-risk screening program? A retrospective cohort study in a population-based cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dementia risk reduction is a global public health priority. Existing primary prevention approaches have favored individual-level interventions, with a research and policy gap for population-level interventions. We conducted a complex, multi-stage, evidence review to identify empirical evidence on population-level interventions for each of the modifiable risk factors identified by the Lancet Commission on dementia (2020). Through a comprehensive series of targeted searches, we identified 4604 articles, of which 135 met our inclusion criteria. We synthesized evidence from multiple sources, including existing non-communicable disease prevention frameworks, and graded the consistency and comprehensiveness of evidence. We derived a population-level intervention framework for dementia risk reduction, containing 26 high- and moderate-confidence policy recommendations, supported by relevant information on effect sizes, sources of evidence, contextual information, and implementation guidance. This review provides policymakers with the evidence they need, in a useable format, to address this critical public health policy gap. Funding: SW is funded by a National Institute for Health and Care Research (NIHR) Doctoral Fellowship. WW and LF are part funded by the NIHR Applied Research Collaboration East of England. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.