Evidence map›Paper›PMID 38495441›Full record

ReviewBiophysical reviews2024

Representing and extracting knowledge from single-cell data.

Ionut Sebastian Mihai, Sarang Chafle, Johan Henriksson

Abstract readReview
In one paragraph

Review in Biophysical reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Biophysical reviews · 2024
    Article
  2. Biophysical Reviews: peering into 2024.Biophysical reviews · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ionut Sebastian MihaiThe Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå, Sweden.ORCID 0000-0002-9322-5879
Sarang ChafleThe Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå, Sweden.ORCID 0000-0003-2475-3528
Johan HenrikssonThe Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå, Sweden.ORCID 0000-0002-7745-2844

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single-cell analysis is currently one of the most high-resolution techniques to study biology. The large complex datasets that have been generated have spurred numerous developments in computational biology, in particular the use of advanced statistics and machine learning. This review attempts to explain the deeper theoretical concepts that underpin current state-of-the-art analysis methods. Single-cell analysis is covered from cell, through instruments, to current and upcoming models. The aim of this review is to spread concepts which are not yet in common use, especially from topology and generative processes, and how new statistical models can be developed to capture more of biology. This opens epistemological questions regarding our ontology and models, and some pointers will be given to how natural language processing (NLP) may help overcome our cognitive limitations for understanding single-cell data.

Indexed as

Generating processesGraphsMarkov chainsNeural networksNLPSingle-cellStatisticsTopologyVAE

Identifiers

PMID38495441
PMCPMC10937862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.