Stereocomplexed Functional and Statistical Poly(lactide-carbonate)s via a Simple Organocatalytic System.

Panagiotis Bexis, Jonathan T Husband, Haritz Sardon, Olivier Coulembier, Andrew P Dove

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Article in Macromolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Panagiotis BexisSchool of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.

Jonathan T HusbandSchool of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.

Haritz SardonPOLYMAT, University of the Basque Country UPV/EHU, Joxe Mari Korta Center, Avda. Tolosa 72, 20018 Donostia-San Sebastian, Spain.ORCID https://orcid.org/0000-0002-6268-0916

Olivier CoulembierCenter of Innovation and Research in Materials and Polymers (CIRMAP), Laboratory of Polymeric and Composite Materials, University of Mons, Mons B-7000, Belgium.ORCID https://orcid.org/0000-0001-5753-7851

Andrew P DoveSchool of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.ORCID https://orcid.org/0000-0001-8208-9309

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The stereocomplexation of polylactide (PLA) has been widely relied upon to develop degradable, sustainable materials with increased strength and improved material properties in comparison to stereopure PLA. However, forming functionalized copolymers of PLA while retaining high crystallinity remains elusive. Herein, the controlled ring-opening copolymerization (ROCOP) of lactide (LA) and functionalized cyclic carbonate monomers is undertaken. The produced polymers are shown to remain crystalline up to 25 mol % carbonate content and are efficiently stereocomplexed with homopolymer PLA and copolymers of opposite chirality. Polymers with alkene and alkyne pendent handles are shown to undergo efficient derivatization with thiol-ene click chemistry, which would allow both the covalent conjugation of therapeutic moieties and tuning of material properties.

Identifiers

PMID38495388

DOI10.1021/acs.macromol.3c02485

PMCPMC10938874

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.