Evidence map›Paper›PMID 38495100›Full record

ArticleFrontiers in pharmacology2024

Neutrophil elastase as a versatile cleavage enzyme for activation of αvβ3 integrin-targeted small molecule drug conjugates with different payload classes in the tumor microenvironment.

Anne-Sophie Rebstock, Mareike Wiedmann, Beatrix Stelte-Ludwig, Harvey Wong, Amy J Johnson, Raquel Izumi, Ahmed Hamdy, Hans-Georg Lerchen

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anne-Sophie RebstockVincerx Pharma GmbH, Monheim, Germany.
Mareike WiedmannVincerx Pharma GmbH, Monheim, Germany.
Beatrix Stelte-LudwigVincerx Pharma GmbH, Monheim, Germany.
Harvey WongVincerx Pharma, Inc., Palo Alto, CA, United States.
Amy J JohnsonVincerx Pharma, Inc., Palo Alto, CA, United States.
Raquel IzumiVincerx Pharma, Inc., Palo Alto, CA, United States.
Ahmed HamdyVincerx Pharma, Inc., Palo Alto, CA, United States.
Hans-Georg LerchenVincerx Pharma GmbH, Monheim, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

camptothecinneutrophil elastase (NE)small molecule drug conjugatetumor microenvironmentαvβ3 integrin

Identifiers

PMID38495100
PMCPMC10943695
OpenAlexW4392352445

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.