Evidence map›Paper›PMID 38494932›Full record

ReviewCurrent cancer drug targets2025

Withanone as an Emerging Anticancer Agent and Understanding Its Molecular Mechanisms: Experimental and Computational Evidence.

Annatasha Stephen, Bernadette Xin Jie Tune, Yuan Seng Wu, Kalaivani Batumalaie, Mahendran Sekar, Md Moklesur Rahman Sarker, Vetriselvan Subramaniyan, Neeraj Kumar Fuloria, Shivkanya Fuloria, Subash C B Gopinath

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current cancer drug targets, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Pharmacological and Phytochemical Insights IntoFood science & nutrition · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 4 countries.

Annatasha StephenDepartment of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur, 50603, Malaysia.ORCID 0000-0001-9909-4948
Bernadette Xin Jie TuneDepartment of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur, 50603, Malaysia.ORCID 0000-0003-4359-3806
Yuan Seng WuSunway Microbiome Centre, School of Medical and Life Sciences, Sunway University, Subang Jaya, 47500, Selangor, Malaysia.ORCID 0000-0001-5574-8049
Kalaivani BatumalaiePre-University Programmes, Sunway College Johor Bahru, Jalan Austin Heights Utama, Taman Mount Austin, 81100, JohorBahru, Johor, Malaysia.ORCID 0000-0002-9569-5014
Mahendran SekarSchool of Pharmacy, Monash University Malaysia, Bandar Sunway, Subang Jaya, 47500, Malaysia.ORCID 0000-0002-3022-6137
Md Moklesur Rahman SarkerDepartment of Pharmacy, State University of Bangladesh, 77, Satmasjid Road, Dhanmondi, Dhaka, 1205, Bangladesh.ORCID 0000-0001-9795-0608
Vetriselvan SubramaniyanPharmacology Unit, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, 47500, Subang Jaya, Selangor, Malaysia.ORCID 0000-0002-9629-9494
Neeraj Kumar FuloriaCentre of Excellence for Biomaterials Engineering, Faculty of Pharmacy, AIMST University, Bedong, 08100, Kedah, Malaysia.ORCID 0000-0002-8970-5212
Shivkanya FuloriaFaculty of Pharmacy, AIMST University, Semeling, Bedong, Kedah, 08100, Malaysia.ORCID 0000-0002-5381-5655
Subash C B GopinathFaculty of Chemical Engineering Technology, Universiti Malaysia Perlis, Arau, 02600, Perlis, Malaysia.ORCID 0000-0002-8347-4687
AIMST University · MYUniversity of Malaya · MYLovely Professional University · INMonash University Malaysia · MYNewcastle University Medicine Malaysia · MYState University of Bangladesh · BDSunway University · MYUniversiti Malaysia Perlis · MY

Funding

Fundamental Research Grant Scheme FRGS/1/2019/SKK10/MAHSA/03/1Sunway University research grant GRTIN-IGS-CVVR[S]-03-2022
6 · The paper itself

Abstract

Despite decades of research and effort, treating cancer is still a challenging task. Current conventional treatments are still unsatisfactory to fully eliminate and prevent re-emergence or relapses, and targeted or personalised therapy, which are more effective in managing cancer, may be unattainable or inaccessible for some. In the past, research in natural products have yielded some of the most commonly used cancer treatment drugs known today. Hence it is possible more are awaiting to be discovered. Withanone, a common withanolide found in the Ayurvedic herb

Indexed as

Antineoplastic AgentsAntineoplastic Agents, PhytogenicNeoplasmsWithanolidesAnimalsHumansAntineoplastic AgentsAntineoplastic Agents, PhytogenicWithanolidesanticancer agent.Cancercancer treatmentmolecular mechanismsWithania somniferawithanone

Identifiers

PMID38494932
OpenAlexW4392919390

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.