Evidence map›Paper›PMID 38494843›Full record

ArticleJournal of cellular and molecular medicine2024

Avocado-derived extracellular vesicles loaded with ginkgetin and berberine prevent inflammation and macrophage foam cell formation.

Shweta Sharma, Manisha Mahanty, Suneha G Rahaman, Pritha Mukherjee, Bidisha Dutta, Mohammad Imran Khan, Karunakaran Reddy Sankaran, Xiaoming He, Lakshmyya Kesavalu, Wei Li and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Shweta SharmaDepartment of Nutrition and Food Science, University of Maryland, College Park, Maryland, USA.
Manisha MahantyDepartment of Nutrition and Food Science, University of Maryland, College Park, Maryland, USA.
Suneha G RahamanDepartment of Nutrition and Food Science, University of Maryland, College Park, Maryland, USA.
Pritha MukherjeeDepartment of Nutrition and Food Science, University of Maryland, College Park, Maryland, USA.
Bidisha DuttaDepartment of Nutrition and Food Science, University of Maryland, College Park, Maryland, USA.
Mohammad Imran KhanDepartment of Nutrition and Food Science, University of Maryland, College Park, Maryland, USA.
Karunakaran Reddy SankaranDepartment of Nutrition and Food Science, University of Maryland, College Park, Maryland, USA.
Xiaoming HeFischell Department of Bioengineering, University of Maryland, College Park, Maryland, USA.
Lakshmyya KesavaluDepartment of Periodontology and Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida, USA.
Wei LiDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA.
Shaik O RahamanDepartment of Nutrition and Food Science, University of Maryland, College Park, Maryland, USA.ORCID 0000-0002-6481-392X
University of Maryland, College Park · USMarshall University · USUniversity of Florida · US

Funding

National Institute of Health, USA R01EB024556
6 · The paper itself

Abstract

Atherosclerosis, a chronic inflammatory disease of aorta, remains the major cause of morbidity and mortality among cardiovascular disease patients. Macrophage foam cell formation and inflammation are critically involved in early stages of atherosclerosis, hence chemopreventive targeting of foam cell formation by nutraceuticals may be a promising approach to curbing the progression of atherosclerosis. However, many nutraceuticals including berberine and ginkgetin have low stability, tissue/cell penetration and bioavailability resulting in inadequate chemotherapeutic effects of these nutraceuticals. We have used avocado-derived extracellular vesicles (EV) isolated from avocado (EV

Indexed as

AtherosclerosisBerberineBiflavonoidsPerseaFoam CellsHumansLipoproteins, LDLMacrophagesBerberineBiflavonoidsginkgetinLipoproteins, LDLavocado-derived extracellular vesiclesmacrophage foam cellsnutraceuticaloxLDL

Identifiers

PMID38494843
PMCPMC10945093
OpenAlexW4392925870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.