Article in Cerebral cortex (New York, N.Y. : 1991), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 4 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
7 authors at 2 institutions in 2 countries.
Dylan S SpetsClinical Neuroscience Laboratory for Sex Differences in the Brain, Department of Psychiatry, Massachusetts General Hospital, 149 13th Street, Boston, MA 02129, USA.ORCID 0000-0001-8730-3917
Justine E CohenClinical Neuroscience Laboratory for Sex Differences in the Brain, Department of Psychiatry, Massachusetts General Hospital, 149 13th Street, Boston, MA 02129, USA.
Kyoko KonishiClinical Neuroscience Laboratory for Sex Differences in the Brain, Department of Psychiatry, Massachusetts General Hospital, 149 13th Street, Boston, MA 02129, USA.
Sarah AronerClinical Neuroscience Laboratory for Sex Differences in the Brain, Department of Psychiatry, Massachusetts General Hospital, 149 13th Street, Boston, MA 02129, USA.
Madhusmita MisraDepartment of Medicine, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Hang LeeInnovation Center on Sex Differences in Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Jill M GoldsteinClinical Neuroscience Laboratory for Sex Differences in the Brain, Department of Psychiatry, Massachusetts General Hospital, 149 13th Street, Boston, MA 02129, USA.
Harvard University · USMassachusetts General Hospital · US
Funding
Sex Differences in Major Depression, Part II: Impact of Prenatal Immune, Autonomic and Neurovascular FunctionU54MH118919 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI STUART A. TOBET · 2020 to 2026
$12.7M
Hormones/Genes in Women's Health: From Bench to BedsideK12HD051959 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLDSTEIN, JILL M, REXRODE, KATHRYN M · 2005 to 2023
$8.8M
Aging of Emotion Circuitry: Impact of Sex, Depression, and Fetal Immune OriginsR01AG057505 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI JILL M GOLDSTEIN · 2018 to 2026
$8.5M
Stuart T. Hauser Research Training Program in Biological and Social Psychiatry.T32MH016259 · NIMH · JUDGE BAKER CHILDREN'S CENTER · PI Marek Kubicki, Martha E. Shenton · 1985 to 2026
$8.4M
Impact of sex differences in immune function on shared risk for cardiometabolic disorder & Alzheimer's diseaseRF1AG074008 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GOLDSTEIN, JILL M · 2021 to 2021
$3.8M
Fetal Hormonal Programming of Sex Differences in Aging of the Memory CircuitryR01MH090291 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLDSTEIN, JILL M · 2011 to 2015
$3.5M
Impact of sex differences in immune function on shared risk for cardiometabolic disorder & Alzheimer's diseaseR01AG074008 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GOLDSTEIN, JILL M · 2024 to 2025
$2.5M
Sex Differences in Alzheimer's disease-Related Pathology: Role of Mitochondrial Function and Metabolic HealthK01AG081500 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Kyoko Konishi · 2023 to 2026
$514k
Fetal Hormonal Programming of Sex Differences in Aging of the Memory Circuitry (Phase II)R56MH090291 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLDSTEIN, JILL M · 2016 to 2016
Alterations to the resting-state default mode network (rsDMN) are early indicators of memory decline and Alzheimer's disease (AD). Brain regions shared by the rsDMN and memory circuitry are highly sexually dimorphic. However, data are limited regarding the impact of sex and reproductive status on rsDMN connectivity and memory circuitry and function. In the current investigation, rsDMN connectivity was assessed in 180 early midlife adults aged 45 to 55 by sex and reproductive status (87 women; 93 men). Associations between left and right hippocampal connectivity of rsDMN and verbal memory encoding circuitry were examined using linear mixed models, controlled for age and parental socioeconomic status, testing interactions by sex and reproductive status. Relative to men, women exhibited greater rsDMN connectivity between the left and right hippocampus. In relation to rsDMN-memory encoding connectivity, sex differences were revealed across the menopausal transition, such that only postmenopausal women exhibited loss of the ability to decrease rsDMN left-right hippocampal connectivity during memory encoding associated with poorer memory performance. Results demonstrate that sex and reproductive status play an important role in aging of the rsDMN and interactions with memory circuitry/function. This suggests the critical importance of sex and reproductive status when studying early midlife indicators of memory decline and AD risk.
Indexed as
AgingDefault Mode NetworkBrainFemaleHumansMaleMemory DisordersMenopauseMiddle AgedDMNestradiolhippocampusmenopauseresting state
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Impact of sex and reproductive status on the default mode network in early midlife: implications for aging of memory circuitry and function. · full record | OpenQuestion