Evidence map›Paper›PMID 38494389›Full record

ReviewInternational dental journal2024

MSCs-Derived Decellularised Matrix: Cellular Responses and Regenerative Dentistry.

Suphalak Phothichailert, Shirel Samoun, Benjamin P Fournier, Juliane Isaac, Sindy Cornelia Nelwan, Thanaphum Osathanon, Nunthawan Nowwarote

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International dental journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Suphalak PhothichailertCenter of Excellence for Dental Stem Cell Biology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Shirel SamounCentre de Recherche des Cordeliers, Université Paris Cité, Sorbonne Universite, INSERM UMRS1138, Molecular Oral Pathophysiology, Paris, France.
Benjamin P FournierCentre de Recherche des Cordeliers, Université Paris Cité, Sorbonne Universite, INSERM UMRS1138, Molecular Oral Pathophysiology, Paris, France; Department of Oral Biology, Faculty of Dentistry, Université Paris Cité, Paris, France.
Juliane IsaacCentre de Recherche des Cordeliers, Université Paris Cité, Sorbonne Universite, INSERM UMRS1138, Molecular Oral Pathophysiology, Paris, France; Department of Oral Biology, Faculty of Dentistry, Université Paris Cité, Paris, France.
Sindy Cornelia NelwanDepartment of Pediatric Dentistry, Faculty of Dental Medicine, Universitas Airlangga, Airlangga, Indonesia.
Thanaphum OsathanonCenter of Excellence for Dental Stem Cell Biology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand; Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand. Electronic address: thanaphum.o@chula.ac.th.
Nunthawan NowwaroteCentre de Recherche des Cordeliers, Université Paris Cité, Sorbonne Universite, INSERM UMRS1138, Molecular Oral Pathophysiology, Paris, France; Department of Oral Biology, Faculty of Dentistry, Université Paris Cité, Paris, France. Electronic address: p_now@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The decellularised extracellular matrix (dECM) of in vitro cell culture is a naturally derived biomaterial formed by the removal of cellular components. The compositions of molecules in the extracellular matrix (ECM) differ depending on various factors, including the culture conditions. Cell-derived ECM provides a 3-dimensional structure that has a complex influence on cell signalling, which in turn affects cell survival and differentiation. This review describes the effects of dECM derived from mesenchymal stem cells (MSCs) on cell responses, including cell migration, cell proliferation, and cell differentiation in vitro. Published articles were searched in the PubMed databases in 2005 to 2022, with assigned keywords (MSCs and decellularisation and cell culture). The 41 articles were reviewed, with the following criteria. (1) ECM was produced exclusively from MSCs; (2) decellularisation processes were performed; and (3) the dECM production was discussed in terms of culture systems and specific supplementations that are suitable for creating the dECM biomaterials. The dECM derived from MSCs supports cell adhesion, enhances cell proliferation, and promotes cell differentiation. Importantly, dECM derived from dental MSCs shows promise in regenerative dentistry applications. Therefore, the literature strongly supports cell-based dECMs as a promising option for innovative tissue engineering approaches for regenerative medicine.

Indexed as

Cell DifferentiationCell ProliferationMesenchymal Stem CellsTissue EngineeringBiocompatible MaterialsCell AdhesionCell Culture TechniquesCell MovementDecellularized Extracellular MatrixExtracellular MatrixHumansRegenerative MedicineBiocompatible MaterialsDecellularized Extracellular MatrixCell differentiationCell proliferationDecellularisationExtracellular matrixMesenchymal stem cellRegenerative dentistry

Identifiers

PMID38494389
PMCPMC11123543

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.