Evidence map›Paper›PMID 38494247›Full record

ArticleJournal, genetic engineering & biotechnology2024

Ameliorating orthodontic relapse using laser bio-stimulation and mesenchymal stem cells in rats.

Samer S Othman, Ali Saafan, Mohammad M F Al-Halbosiy, Iman Fathy, Mohamed Khursheed Alam, Amr R El-Beialy, Hanady S Al-Shmgani, Ghassan M Sulaiman

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal, genetic engineering & biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Samer S OthmanDepartment of Clinical Sciences, College of Dentistry, Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq.
Ali SaafanDepartment of Medical Applications of Laser, National Institute for Laser Enhanced Sciences, Cairo University, Cairo, Egypt.
Mohammad M F Al-HalbosiyBiotechnology Research Center, Al-Nahrain University, Baghdad, Iraq.
Iman FathyDepartment of Oral Biology, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.
Mohamed Khursheed AlamProfessor of Orthodontics, Department of Preventive Dentistry, College of Dentistry, Jouf University, Sakakah, Saudi Arabia.
Amr R El-BeialyDepartment of Orthodontics and Dentofacial Orthopedics, Faculty of Dentistry, Cairo University, Cairo, Egypt. Electronic address: amr.elbeialy@dentistry.cu.edu.eg.
Hanady S Al-ShmganiDepartment of Biology, College of Education for Pure Sciences, Ibn Al-Haitham University of Baghdad, Baghdad 10066, Iraq. Electronic address: hanadi.s.as@ihcoedu.uobaghdad.edu.iq.
Ghassan M SulaimanDivision of Biotechnology, Department of Applied Sciences, University of Technology, Baghdad 10066, Iraq.
Cairo University · EGAin Shams University · EGAl Jouf University · SANahrain University · IQUniversity of Baghdad · IQUniversity of Technology - Iraq · IQ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOrthodontic relapse is a frequent problem that many patients experience. Although orthodontic therapy has advanced, recurrence rates can still reach 90%. We undertook a study to look at the possibilities of laser bio-stimulation and stem cells because they have showed promising outcomes in lowering recurrence rates.

objectivesOur objective was to analyze the effects of Low-level laser therapy (LLLT) and Mesenchymal stem cells (MSC) alone and collectively on the rate of orthodontic relapse in rats radiographically and histologically.

methodsRat maxillary central incisors were moved distally for two weeks. One week later, the incisors were retained. Animals (n = 40) were split into four groups. Control group (C); laser treatment Group (L), Bone marrow mesenchymal stem cells Group (BMSCs) and combination of Stem cells and laser-irradiation group (BMSCs-L). Removed retainer permitted relapse. Before stem cell application or laser irradiation, each animal underwent two CBCT scans. Rat maxillae were stained with Hx&E, Masson trichrome, and tartrate-resistant acid phosphatase antibody for histology, histochemistry, and immunohistochemistry. RESULTS AND

conclusionsLLLT could reduce the relapse tendency, as shown by increased bone density and enhanced remodeling of hetero-formed periodontal ligament (PDL). Furthermore, the transfer of BMMSCs on the pressure side had positive effects on PDL remodeling and decreased, but did not inhibit, the relapse rate. Finally, the synergistic effects of the application of LLLT and BMMSC were better than the control but still moderate and long-lasting. CLINICAL SIGNIFICANCE: Based on the improved relapse rate as proven in the present study, the Application of both LLLT and stem cells can be adopted to reduce the relapse tendency either lonely or collectively.

Indexed as

Hetero-formed periodontal ligamentLaser irradiationLow-level laser treatmentMesenchyme stem cellsOrthodontic relapse

Identifiers

PMID38494247
PMCPMC10980849
OpenAlexW4391088672

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.