Evidence map›Paper›PMID 38493902›Full record

ArticleInternational journal of radiation oncology, biology, physics2024

Multi-Institutional Audit of FLASH and Conventional Dosimetry With a 3D Printed Anatomically Realistic Mouse Phantom.

M Ramish Ashraf, Stavros Melemenidis, Kevin Liu, Veljko Grilj, Jeannette Jansen, Brett Velasquez, Luke Connell, Joseph B Schulz, Claude Bailat, Aaron Libed and 15 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of radiation oncology, biology, physics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Investigating the oxygen dependence of FLASH-RT using electron paramagnetic resonance imaging.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Efficacy of Radiotherapy FLASH-RT: From Treating Lung Cancer to Preventing Pulmonary Fibrosis.Dose-response : a publication of International Hormesis Society
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

M Ramish AshrafDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
Stavros MelemenidisDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
Kevin LiuDepartment of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Veljko GriljInstitute of Radiation Physics, Lausanne University Hospital and University of Lausanne, Switzerland.
Jeannette JansenRadiation Oncology Laboratory, Department of Radiation Oncology, Lausanne, University Hospital and University of Lausanne, Switzerland.
Brett VelasquezDepartment of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Luke ConnellDepartment of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Joseph B SchulzDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
Claude BailatInstitute of Radiation Physics, Lausanne University Hospital and University of Lausanne, Switzerland.
Aaron LibedDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
Rakesh ManjappaDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
Suparna DuttDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
Luis SotoDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
Brianna LauDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
Aaron GarzaDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
William LarsenDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
Lawrie SkinnerDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
Amy S YuDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
Murat SurucuDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
Edward E GravesDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California.
Peter G MaximDepartment of Radiation Oncology, University of California, Irvine, California.
Stephen F KryDepartment of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Imaging and Radiation Oncology Core, MD Anderson Cancer Center, Houston, USA.
Marie-Catherine VozeninRadiation Oncology Laboratory, Department of Radiation Oncology, Lausanne, University Hospital and University of Lausanne, Switzerland; Radiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland. Electronic address: marie-catherine.vozenin@hcuge.ch.
Emil SchülerDepartment of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: eschueler@mdanderson.org.
Billy W LooDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California. Electronic address: bwloo@stanford.edu.

Funding

Project 4: Mechanistic Basics of FLASH Effect: Role of O2P01CA244091 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIMOLI, CHARLES · 2020 to 2024
$9.6M
Research Supplements to Promote Diversity in Health-Related Research: Preclinical optimization of ultra-high dose rate (FLASH) radiotherapy parameters for translational relevanceR01CA266673 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SCHUELER, EMIL · 2022 to 2025
$3.5M
NCI NIH HHS P01 CA244091NCI NIH HHS R01 CA266673
6 · The paper itself

Abstract

purposeWe conducted a multi-institutional dosimetric audit between FLASH and conventional dose rate (CONV) electron irradiations by using an anatomically realistic 3-dimensional (3D) printed mouse phantom. METHODS AND MATERIALS: A computed tomography (CT) scan of a live mouse was used to create a 3D model of bony anatomy, lungs, and soft tissue. A dual-nozzle 3D printer was used to print the mouse phantom using acrylonitrile butadiene styrene (∼1.02 g/cm

resultsCompared with the reference CT scan, CT scans of the phantom demonstrated mass density differences of 0.10 g/cm

conclusionsThis study marks the first dosimetric audit for FLASH using a nonhomogeneous phantom, challenging conventional calibration practices reliant on homogeneous phantoms. The comparison protocol offers a framework for credentialing multi-institutional studies in FLASH preclinical research to enhance reproducibility of biologic findings.

Indexed as

LungPhantoms, ImagingPrinting, Three-DimensionalTomography, X-Ray ComputedAcrylic ResinsAnimalsBone and BonesButadienesElectronsMicePolyestersPolystyrenesRadiometryRadiotherapy DosageABS resinAcrylic ResinsButadienesPolyesterspoly(lactide)Polystyrenes

Identifiers

PMID38493902
PMCPMC12359262

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.