ArticleCell reports2024
Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 26 citations in OpenAlex.
- A cross-species post-translational modification profiling of histones by LC-MS/MS revealed conserved oxidative modifications in plants.The New phytologist · 2026Article
- Epithelial-mesenchymal transition in carcinoma: navigating phenotypic states to target resistance and metastasis.Cancer metastasis reviews · 2026Review
- Epigenetic regulation and ROS signaling in plant stress adaptation: an integrated framework.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Review
- O-SNAP uncovers nanoscale chromatin remodeling in dedifferentiation and stress responses.Nature communications · 2026Article
- Cysteine addiction in drug resistant glioblastoma and therapeutic targeting with designer selenium compounds.Neuro-oncology · 2026Article
- Single amino-acid differences define H2B variants and modify chromatin accessibility to induce EMT in breast cancer.Oncogene · 2026Article
- Tumor-infiltrating bacteria disrupt cancer epithelial cell interactions and induce cell-cycle arrest.Cancer cell · 2026Article
- Time-resolved multiomics profiling reveals chromatin O-GlcNAc modification promotes senescence-associated transcriptional program.Nature communications · 2026Article
- Epigenetic plasticity and chemoresistance in cancer: mechanisms, biomarkers, and translational opportunities for real-world evidence.Frontiers in cell and developmental biology · 2026Review
- Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Impact of oxidative stress on malignant tumor progression and emerging therapeutic strategies.Frontiers in molecular biosciences · 2026Review
- Identification of a lipid oxygen radical defense pathway and its epigenetic control.Nature communications · 2025Article
- Extracellular Vesicle-Mediated Regulation of H3C14 Contributes to Gemcitabine Resistance in Bladder Cancer.Journal of extracellular vesicles · 2025Article
- Sensing within: Mitochondrial inside-out signal transduction.Cell chemical biology · 2025Review
- Aere perennius: how chromatin fidelity is maintained and lost in disease.NAR molecular medicine · 2025Review
- Geometrically encoded positioning of introns, intergenic segments, and exons in the human genome.bioRxiv : the preprint server for biology · 2025Article
- Miro1 expression alters global gene expression, ERK1/2 phosphorylation, oxidation and cell cycle progression.Journal of cell science · 2025Article
- Unraveling the nexus: Genomic instability and metabolism in cancer.Cell reports · 2025Review
- Neutrophil extracellular traps in tumor metabolism and microenvironment.Biomarker research · 2025Review
- Global maintenance of histone post-translational modifications during the transition into anoxia in embryos of the annual killifishEnvironmental epigenetics · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 8 institutions in 1 country.
Flavio R PalmaDepartment of Medicine, Division of Hematology Oncology, Northwestern University Feinberg School of Medicine and the Robert H. Lurie Comprehensive Cancer Center of Chicago, Chicago, IL 60611, USA.
Diego R CoelhoDepartment of Medicine, Division of Hematology Oncology, Northwestern University Feinberg School of Medicine and the Robert H. Lurie Comprehensive Cancer Center of Chicago, Chicago, IL 60611, USA.
Kirthi PulakantiVersiti Blood Research Institute of Wisconsin, and Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA; Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Marcelo J SakiyamaDepartment of Medicine, Division of Hematology Oncology, Northwestern University Feinberg School of Medicine and the Robert H. Lurie Comprehensive Cancer Center of Chicago, Chicago, IL 60611, USA.
Yunping HuangDepartment of Medicine, Division of Hematology Oncology, Northwestern University Feinberg School of Medicine and the Robert H. Lurie Comprehensive Cancer Center of Chicago, Chicago, IL 60611, USA.
Fernando T OgataDepartment of Medicine, Division of Hematology Oncology, Northwestern University Feinberg School of Medicine and the Robert H. Lurie Comprehensive Cancer Center of Chicago, Chicago, IL 60611, USA.
Jeanne M DanesDepartment of Medicine, Division of Hematology Oncology, Northwestern University Feinberg School of Medicine and the Robert H. Lurie Comprehensive Cancer Center of Chicago, Chicago, IL 60611, USA.
Alison MeyerVersiti Blood Research Institute of Wisconsin, and Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA; Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Cristina M FurduiDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Douglas R SpitzFree Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52245, USA.
Ana P GomesMolecular Oncology Program, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Benjamin N GantnerDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Sridhar RaoVersiti Blood Research Institute of Wisconsin, and Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA; Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Vadim BackmanDepartment of Biomedical Engineering, Northwestern University McCormick School of Engineering, Evanston, IL 60208, USA.
Marcelo G BoniniDepartment of Medicine, Division of Hematology Oncology, Northwestern University Feinberg School of Medicine and the Robert H. Lurie Comprehensive Cancer Center of Chicago, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: marcelo.bonini@northwestern.edu.
Robert H. Lurie Comprehensive Cancer Center of Northwestern UniversityNorthwestern University · USMedical College of Wisconsin · USVersiti Blood Center of Wisconsin · USMcCormick (United States) · USMoffitt Cancer Center · USUniversity of Iowa · USWake Forest University · US
Funding
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0MPulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MSequencing Coordination and Data Analysis CoreP01HL149620 · NHLBI · UNIVERSITY OF ARIZONA · PI GEURTS, ARON M · 2020 to 2024
$11.8MTechnology Development UnitU54CA268084 · NCI · NORTHWESTERN UNIVERSITY · PI Vadim Backman, Daniela E Matei · 2022 to 2026
$10.0MStudying E-cadherin dynamics during extravasation and metastatic colonizationU54CA261694 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ROGER D KAMM, Vivek Shenoy · 2021 to 2026
$9.1MTranslating buccal nanocytology for lung cancer screening into clinical practiceR01CA225002 · NCI · NORTHWESTERN UNIVERSITY · PI Vadim Backman, HARIHARAN SUBRAMANIAN · 2018 to 2026
$5.0MA redox-sensitive switch in the macrophage nucleus regulates acute phaseinflammatory injuryR01HL163820 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BONINI, MARCELO G., GANTNER, BENJAMIN N. · 2022 to 2025
$2.3MMacrophage Redox State in Sterilizing and Injurious InflammationR01AI131267 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BONINI, MARCELO G. · 2017 to 2021
$2.1MDefining GATA4’s Molecular Function in Gastric Cell BiologyR01DK134064 · NIDDK · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI BATTLE, MICHELE A, RAO, SRIDHAR · 2022 to 2025
$2.1MMNSOD ACETYLATION PROMOTES CANCER STEM CELL PHENOTYPES IN BREAST CANCERR01CA216882 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BONINI, MARCELO G. · 2018 to 2022
$1.9MEnvironmental Arsenic in the Subtype Specification of Breast CancerR01ES028149 · NIEHS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BONINI, MARCELO G. · 2018 to 2022
$1.8MH3 histone oxidation is a new posttranslational modification linking heavy metal-induced metabolic changes and oncegenic epigenetic reprogrammingR01ES035723 · NIEHS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Marcelo G. Bonini · 2024 to 2026
$1.2MNCI NIH HHS P30 CA086862NCI NIH HHS R01 CA216882NCI NIH HHS R01 CA225002NCI NIH HHS U54 CA261694NHLBI NIH HHS P01 HL149620NHLBI NIH HHS R01 HL163820NIAID NIH HHS R01 AI131267NIDDK NIH HHS R01 DK134064NIEHS NIH HHS P30 ES005605NIEHS NIH HHS R01 ES028149NIEHS NIH HHS R01 ES035723
Abstract
Chromatin structure is regulated through posttranslational modifications of histone variants that modulate transcription. Although highly homologous, histone variants display unique amino acid sequences associated with specific functions. Abnormal incorporation of histone variants contributes to cancer initiation, therapy resistance, and metastasis. This study reports that, among its biologic functions, histone H3.1 serves as a chromatin redox sensor that is engaged by mitochondrial H
Indexed as
Breast NeoplasmsHistonesChromatinDrug Resistance, MultipleFemaleHumansHydrogen PeroxideChromatinHistonesHydrogen Peroxidebreast cancerchemoresistanceCP: Cancerdrug resistanceEMTH3histone variantsmetastasisredoxROSthiol oxidation
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.