Evidence map›Paper›PMID 38493283›Full record

Trial reportAIDS and behavior2024

Mindfulness-Based Stress Reduction for Symptom Management in Older Individuals with HIV-Associated Neurocognitive Disorder.

Judith T Moskowitz, Brijesh Sharma, Shireen Javandel, Patricia Moran, Robert Paul, Victor De Gruttola, Dimitre Tomov, Haleem Azmy, Rodrigo Sandoval, Madeline Hillis and 9 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in AIDS and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 1 country.

Judith T Moskowitz *Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Judith.moskowitz@northwestern.edu.ORCID http://orcid.org/0000-0002-1399-3318
Brijesh Sharma *Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
Shireen JavandelDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
Patricia MoranOsher Center for Integrative Health, University of California, San Francisco, CA, USA.
Robert PaulMissouri Institute of Mental Health, University of Missouri-St. Louis, St. Louis, MO, USA.
Victor De GruttolaDivision of Biostatistics, Herbert Wertheim School of Public Health, University of California San Diego, San Diego, CA, USA.
Dimitre TomovDepartment of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Haleem AzmyDepartment of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Rodrigo SandovalDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
Madeline HillisDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
Karen P ChenDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
Torie TsueiDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
Elizabeth L AddingtonDepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Peter D CummingsDepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Joanna HellmuthDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
Isabel Elaine AllenDepartment of Epidemiology & Biostatistics, University of California, San Francisco, CA, USA.
Beau M AncesDepartment of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Victor ValcourDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
Benedetta MilaniniInovigate GmbH, Basel, Switzerland.
University of California, San Francisco · USNorthwestern University · USWashington University in St. Louis · USUniversity of California San Diego · USUniversity of Missouri–St. Louis · US

Funding

Interventions for Symptom Management in Older Patients with HANDR01NR015223 · NINR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOSKOWITZ, JUDITH T., VALCOUR, VICTOR · 2014 to 2018
$3.5M
Midcareer Mentoring Award for Patient-Oriented Research in HIV and CognitionK24MH098759 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VALCOUR, VICTOR · 2013 to 2017
$887k
NIMH NIH HHS K24MH098759NINR NIH HHS R01NR015223
6 · The paper itself

Abstract

The growing number of people aging with HIV represents a group vulnerable to the symptom burdens of HIV-associated neurocognitive disorder (HAND). Among younger groups, Mindfulness-Based Stress Reduction (MBSR) has been shown to help people living with HIV manage HIV-related and other life stress, and although there is some theoretical and empirical evidence that it may be effective among those with cognitive deficits, the approach has not been studied in older populations with HAND. Participants (n = 180) 55 years or older with HIV and cognitive impairment were randomly assigned to either an 8-week MBSR arm or a waitlist control. We assessed the impact of MBSR compared to a waitlist control on psychological outcomes [stress, anxiety, depression, and quality of life (QOL)] and cognitive metrics (e.g., speed of information processing, working memory, attention, impulsivity) measured at baseline, immediately post intervention (8 weeks) and one month later (16 weeks). Intent to treat analyses showed significant improvement in the MBSR group compared to control on symptoms of depression from baseline to 8 weeks, however, the difference was not sustained at 16 weeks. The MBSR group also showed improvement in perceived QOL from baseline to 16 weeks compared to the waitlist control group. Cognitive performance did not differ between the two treatment arms. MBSR shows promise as a tool to help alleviate the symptom burden of depression and low QOL in older individuals living with HAND and future work should address methods to better sustain the beneficial impact on depression and QOL.

Indexed as

DepressionHIV InfectionsMindfulnessQuality of LifeStress, PsychologicalAgedAnxietyCognitive DysfunctionFemaleHumansMaleMiddle AgedTreatment OutcomeAgingCognitionHIVHIV-associated neurocognitive disorderMindfulness Based Stress Reduction

Identifiers

PMID38493283
OpenAlexW4392877160

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.