Evidence map›Paper›PMID 38493256›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2024

The NADase CD38 is a central regulator in gouty inflammation and a novel druggable therapeutic target.

Paulo Gil Alabarse, Patricia Oliveira, Huaping Qin, Tiffany Yan, Marie Migaud, Robert Terkeltaub, Ru Liu-Bryan

Open access · hybridAbstract read
In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. NADCell communication and signaling : CCS · 2024
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Paulo Gil AlabarseVA San Diego Healthcare System, 111K, 3350 La Jolla Village Drive, San Diego, CA, 92161, USA.
Patricia OliveiraUniversity of California San Diego, La Jolla, San Diego, CA, USA.
Huaping QinUniversity of California San Diego, La Jolla, San Diego, CA, USA.
Tiffany YanUniversity of California San Diego, La Jolla, San Diego, CA, USA.
Marie MigaudDepartment of Pharmacology, F. Whiddon College of Medicine, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA.
Robert TerkeltaubVA San Diego Healthcare System, 111K, 3350 La Jolla Village Drive, San Diego, CA, 92161, USA.
Ru Liu-BryanVA San Diego Healthcare System, 111K, 3350 La Jolla Village Drive, San Diego, CA, 92161, USA. ruliu@ucsd.edu.ORCID http://orcid.org/0000-0002-9611-8163
University of California San Diego · USJohnson & Johnson (United States) · USUSA Mitchell Cancer Institute · USVA San Diego Healthcare System · US

Funding

ATP-Citrate Lyase As A Novel Metabolic Target for OsteoarthritisI01BX002234 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI BRYAN, RU · 2015 to 2022
–
BLRD VA I01 BX002234
6 · The paper itself

Abstract

objectivesCellular NAD

methodsWe studied cultured mouse wild type and CD38 knockout (KO) murine bone marrow derived macrophages (BMDMs) stimulated by monosodium urate (MSU) crystals and used the air pouch gouty inflammation model.

resultsMSU crystals induced CD38 in BMDMs in vitro, associated with NAD

conclusionsCD38 and NAD

Indexed as

ADP-ribosyl Cyclase 1InflammationMacrophagesMice, Inbred C57BLMice, KnockoutNADUric AcidAnimalsArthritis, GoutyCells, CulturedInflammasomesMaleMembrane GlycoproteinsMiceNLR Family, Pyrin Domain-Containing 3 ProteinADP-ribosyl Cyclase 1Cd38 protein, mouseInflammasomesMembrane GlycoproteinsNADNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseUric AcidCD38GoutInflammationMacrophagesNAD+

Identifiers

PMID38493256
PMCPMC11058052
OpenAlexW4392875720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.