ArticleCommunications medicine2024
Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors.
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Article in Communications medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Trial
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- Effect of Hormonal Contraceptives on Circulating Biomarkers of Inflammation, Chemotaxis, Angiogenesis, and Vascular Stress.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026Observational
- The role of genetic liability for psychiatric disorders and personality traits in post covid syndrome: data from three Nordic population cohorts.EClinicalMedicine · 2026Article
- Representativeness of the Danish Blood Donor Study relative to the general population: a cross-sectional assessment.Scientific reports · 2026Article
- Non-invasive biomarkers in assisted reproduction: a comprehensive review for predicting IVF success.Journal of assisted reproduction and genetics · 2026Review
- Towards Objective Major Depressive Disorder Detection: a Systematic Review and Meta-Analysis of Diagnostic Biomarkers.The Psychiatric quarterly · 2025Review
- Associations between past infectious mononucleosis diagnosis and 47 inflammatory and vascular stress biomarkers.Scientific reports · 2025Article
- Interleukin-15 and innate effector cells as predictors of outcome in allogeneic hematopoietic cell transplantation.Frontiers in immunology · 2025Article
- Excessive Urinary p75ecd is a Potential Indicator of Amyotrophic Lateral Sclerosis: An American Cohort Study.Current neuropharmacology · 2025Article
- Immune changes in pregnancy: associations with pre-existing conditions and obstetrical complications at the 20th gestational week-a prospective cohort study.BMC medicine · 2024Article
- Article
- Donor health beyond donation: cardiovascular risk factors in blood donor populations. A cross-sectional study.Blood transfusion = Trasfusione del sangueArticle
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Authors and funding
50 authors at 9 institutions in 2 countries.
Bertram KjerulffDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark. berkje@rm.dk.ORCID http://orcid.org/0000-0001-9953-9521
Joseph DowsettDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5381-2633
Rikke Louise JacobsenDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-7988-7964
Josephine GladovDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-9233-3117
Margit Hørup LarsenDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Agnete Troen LundgaardTranslational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-7447-6560
Karina BanasikTranslational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2489-2499
David WestergaardTranslational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-0128-8432
Susan MikkelsenDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
Khoa Manh DinhDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-1881-5673
Lotte HindhedeDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
Kathrine Agergård KaspersenDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-7973-3623
Michael SchwinnDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-6151-369X
Anders JuulDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-0534-4350
Betina PoulsenDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Birgitte LindegaardDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Carsten Bøcker PedersenBERTHA Big Data Centre for Environment and Health, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-2077-8533
Clive Eric SabelBERTHA Big Data Centre for Environment and Health, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-9180-4861
Henning BundgaardDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Henriette Svarre NielsenDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2106-8103
Janne Amstrup MøllerDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Jens Kjærgaard BoldsenDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
Kristoffer Sølvsten BurgdorfTranslational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Lars Vedel KessingDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Linda Jenny HandgaardDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Lise Wegner ThørnerDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Maria DidriksenDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-4856-496X
Mette NyegaardDepartment of Health Science and Technology, Aalborg University, Aalborg, Denmark.ORCID http://orcid.org/0000-0003-4973-8543
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5526-1070
Niels ØdumLEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Pär I JohanssonDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-9778-5964
Poul JennumDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ruth Frikke-SchmidtDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4084-5027
Sanne Schou BergerCentre for Diagnostics, DTU Health Technology, Technical University of Denmark, 2800, Kgs. Lyngby, Denmark.ORCID http://orcid.org/0000-0002-1440-4909
Søren BrunakTranslational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-0316-5866
Søren JacobsenDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-5654-4993
Thomas Folkmann HansenTranslational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6703-7762
Tine Kirkeskov LundquistDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-8748-3831
Torben Lykke SørensenDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Torben SigsgaardBERTHA Big Data Centre for Environment and Health, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-2043-7571
Kaspar René NielsenDepartment of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark.
Mie Topholm BruunDepartment of Clinical Immunology, Odense University Hospital, Odense, Denmark.ORCID http://orcid.org/0000-0002-8819-5388
Henrik HjalgrimDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-4436-6798
Henrik UllumStatens Serum Institut, Copenhagen, Denmark.
Klaus RostgaardDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6220-9414
Erik SørensenDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Ole Birger Pedersen *Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2312-5976
Sisse Rye Ostrowski *Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5288-3851
Christian Erikstrup *Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-6551-6647
University of Copenhagen · DKCopenhagen University Hospital · DKAarhus University · DKAarhus University Hospital · DKStatens Serum Institut · DKAalborg University · DKAalborg University Hospital · DKOdense University Hospital · DKTechnical University of Denmark · DK
Funding
Augustinus Fonden (Augustinus Foundation) 19-3829Det Frie Forskningsråd (Danish Council for Independent Research) 09-069412Det Frie Forskningsråd (Danish Council for Independent Research) 8020-00403BEC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 101017562Novo Nordisk Fonden (Novo Nordisk Foundation) NNF14CC0001Novo Nordisk Fonden (Novo Nordisk Foundation) NNF17OC0027594Novo Nordisk Fonden (Novo Nordisk Foundation) NNF17OC0027864
Abstract
backgroundThe emerging use of biomarkers in research and tailored care introduces a need for information about the association between biomarkers and basic demographics and lifestyle factors revealing expectable concentrations in healthy individuals while considering general demographic differences.
methodsA selection of 47 biomarkers, including markers of inflammation and vascular stress, were measured in plasma samples from 9876 Danish Blood Donor Study participants. Using regression models, we examined the association between biomarkers and sex, age, Body Mass Index (BMI), and smoking.
resultsHere we show that concentrations of inflammation and vascular stress biomarkers generally increase with higher age, BMI, and smoking. Sex-specific effects are observed for multiple biomarkers.
conclusionThis study provides comprehensive information on concentrations of 47 plasma biomarkers in healthy individuals. The study emphasizes that knowledge about biomarker concentrations in healthy individuals is critical for improved understanding of disease pathology and for tailored care and decision support tools.
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