Evidence map›Paper›PMID 38493193›Full record

ArticleScientific reports2024

Deep sequencing of candidate genes identified 14 variants associated with smoking abstinence in an ethnically diverse sample.

Paul M Cinciripini, David W Wetter, Jian Wang, Robert Yu, George Kypriotakis, Tapsi Kumar, Jason D Robinson, Yong Cui, Charles E Green, Andrew W Bergen and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Paul M Cinciripini *Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. pcinciri@mdanderson.org.
David W WetterDepartment of Department of Population Health Sciences, University of Utah and Huntsman Cancer Institute, Salt Lake City, Utah, 84112, USA.
Jian WangDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Robert YuDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
George KypriotakisDepartment of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. gkypriotakis@mdanderson.org.
Tapsi KumarDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Jason D RobinsonDepartment of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Yong CuiDepartment of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Charles E GreenDepartment of Pediatrics, The University of Texas Medical School at Houston, Houston, TX, 77030, USA.
Andrew W BergenOregon Research Institute, Springfield, OR, 97477, USA.
Thomas R KostenDepartment of Psychiatry, Baylor College of Medicine, Houston, TX, 77030, USA.
Steven E SchererDepartment of Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, 77030, USA.
Sanjay Shete *Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. sshete@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USBaylor College of Medicine · USBaylor Genetics · USHuntsman Cancer Institute · USOregon Research Institute · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
CTSA UM1 Program at University of UtahUM1TR004409 · NCATS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RACHEL HESS, Jennifer Juhl Majersik · 2023 to 2026
$21.9M
SHARED RESOUCES COREP60MD000503 · NIMHD · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI JONES, LOVELL ALLAN · 2003 to 2011
$12.4M
Pharmacogenetics, Emotional Reactivity &Smoking(RMI)R01DA017073 · NIDA · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CINCIRIPINI, PAUL MICHAEL · 2004 to 2009
$3.0M
Effectiveness of Varenicline vs. Varenicline plus Bupropion for Smoking CessationR01DA024709 · NIDA · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CINCIRIPINI, PAUL MICHAEL · 2009 to 2014
$2.9M
Group Therapy for Nicotine DependenceR01DA018875 · NIDA · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WETTER, DAVID W · 2004 to 2009
$2.8M
Treatment of Nicotine Dependence Among HypertensivesR01CA094826 · NCI · UNIVERSITY OF TEXAS MD ANDERSON CAN CTR · PI WETTER, DAVID W · 2001 to 2005
$2.3M
Race/Ethnicity and the Process of Smoking CessationR01DA014818 · NIDA · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WETTER, DAVID W · 2001 to 2006
$2.0M
SCHEDULED SMOKING WITH TRANSDERMAL NICOTINER01DA011822 · NIDA · UNIVERSITY OF TEXAS MD ANDERSON CAN CTR · PI CINCIRIPINI, PAUL MICHAEL · 1998 to 2001
$623k
NCATS NIH HHS UM1 TR004409NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA094826NIDA NIH HHS R01 DA011822NIDA NIH HHS R01 DA014818NIDA NIH HHS R01 DA017073NIDA NIH HHS R01 DA018875NIDA NIH HHS R01 DA024709NIMHD NIH HHS P60 MD000503
6 · The paper itself

Abstract

Despite the large public health toll of smoking, genetic studies of smoking cessation have been limited with few discoveries of risk or protective loci. We investigated common and rare variant associations with success in quitting smoking using a cohort from 8 randomized controlled trials involving 2231 participants and a total of 10,020 common and 24,147 rare variants. We identified 14 novel markers including 6 mapping to genes previously related to psychiatric and substance use disorders, 4 of which were protective (CYP2B6 (rs1175607105), HTR3B (rs1413172952; rs1204720503), rs80210037 on chr15), and 2 of which were associated with reduced cessation (PARP15 (rs2173763), SCL18A2 (rs363222)). The others mapped to areas associated with cancer including FOXP1 (rs1288980) and ZEB1 (rs7349). Network analysis identified significant canonical pathways for the serotonin receptor signaling pathway, nicotine and bupropion metabolism, and several related to tumor suppression. Two novel markers (rs6749438; rs6718083) on chr2 are flanked by genes associated with regulation of bodyweight. The identification of novel loci in this study can provide new targets of pharmacotherapy and inform efforts to develop personalized treatments based on genetic profiles.

Indexed as

Nicotinic AgonistsSmoking CessationBupropionForkhead Transcription FactorsHigh-Throughput Nucleotide SequencingHumansRepressor ProteinsSmokingBupropionForkhead Transcription FactorsFOXP1 protein, humanNicotinic AgonistsRepressor ProteinsCandidate gene studyRare variantSequencingSingle-nucleotide polymorphismSmoking cessation

Identifiers

PMID38493193
PMCPMC10944542
OpenAlexW4392880203

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.