Evidence map›Paper›PMID 38493083›Full record

Trial reportBMC oral health2024

Performance of cone-beam computed tomography (CBCT) in comparison to conventional computed tomography (CT) and magnetic resonance imaging (MRI) for the detection of bone invasion in oral squamous cell cancer (OSCC): a prospective study.

Anton Straub, Christian Linz, Constantin Lapa, Stefan Hartmann, Alexander C Kübler, Urs D A Müller-Richter, Julian Faber, Thorsten Bley, Joachim Brumberg, Olivia Kertels and 1 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Computed Tomography in Predicting the Mandibular Involvement by Oral Cancer, a Retrospective Study.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Anton StraubDepartment of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070, Würzburg, Germany. Straub_A@ukw.de.
Christian LinzDepartment of Oral, Maxillofacial and Plastic Surgery, University of Köln, Faculty of Medicine and University Hospital Köln, Kepenerstr. 62, 50937, Köln, Germany.
Constantin LapaNuclear Medicine, Faculty of Medicine, University of Augsburg, Stenglinstr. 2, 86156, Augsburg, Germany.
Stefan HartmannDepartment of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
Alexander C KüblerDepartment of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
Urs D A Müller-RichterDepartment of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
Julian FaberDepartment of Oral, Maxillofacial and Plastic Surgery, University of Köln, Faculty of Medicine and University Hospital Köln, Kepenerstr. 62, 50937, Köln, Germany.
Thorsten BleyDepartment of Diagnostic and Interventional Radiology, University Hospital Würzburg, Oberdürrbacherstr. 6, 97080, Würzburg, Germany.
Joachim BrumbergDepartment of Nuclear Medicine, Medical Center, Faculty of Medicine, University of Freiburg, University of Freiburg, Hugstetterstr. 55, 79106, Freiburg, Germany.
Olivia KertelsDepartment of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technical University of München, Ismaninger Str. 22, 81675, München, Germany.
Roman C BrandsDepartment of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
Universitätsklinikum Würzburg · DEKlinikum rechts der Isar · DEUniversity Medical Center Freiburg · DEUniversity of Augsburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOral squamous carcinoma (OSCC) is often diagnosed at late stages and bone erosion or invasion of the jawbone is frequently present. Computed tomography (CT) and magnetic resonance imaging (MRI) are known to have high diagnostic sensitivities, specificities, and accuracies in detecting these bone affections in patients suffering from OSCC. To date, the existing data regarding the impact of cone-beam computed tomography (CBCT) have been weak. Therefore, this study aimed to investigate whether CBCT is a suitable tool to detect bone erosion or invasion in patients with OSCC.

methodsWe investigated in a prospective trial the impact of CBCT in the diagnosis of bone erosion or invasion in patients with OSCC who underwent surgery. Every participant received a CBCT, CT, and MRI scan during staging. Imaging modalities were evaluated by two specialists in oral and maxillofacial surgery (CBCT) and two specialists in radiology (CT and MRI) in a blinded way, to determine whether a bone affection was present or not. Reporting used the following 3-point system: no bony destruction ("0"), cortical bone erosion ("1"), or medullary bone invasion ("2"). Histological examination or a follow-up served to calculate the sensitivities, specificities, and accuracies of the imaging modalities.

resultsOur results revealed high diagnostic sensitivities (95.6%, 84.4%, and 88.9%), specificities (87.0%, 91.7%, and 91.7%), and accuracies (89.5%, 89.5%, and 90.8%) for CBCT, CT, and MRI. A pairwise comparison found no statistical difference between CBCT, CT, and MRI.

conclusionOur data support the routine use of CBCT in the diagnosis of bone erosion and invasion in patients with OSCC as diagnostic accuracy is equal to CT and MRI, the procedure is cost-effective, and it can be performed during initial contact with the patient.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsMouth NeoplasmsSpiral Cone-Beam Computed TomographyCone-Beam Computed TomographyEpithelial CellsHumansMagnetic Resonance ImagingProspective StudiesSquamous Cell Carcinoma of Head and NeckTomography, X-Ray ComputedBone invasionBone resectionComputed tomographyCone-beam computed tomographyHead and neck cancerMagnetic resonance imagingMandibulectomyOral cancerOral squamous cell carcinoma

Identifiers

PMID38493083
PMCPMC10944617
OpenAlexW4392879401

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.