Evidence map›Paper›PMID 38492716›Full record

ArticleResuscitation2024

Brain computed tomography after resuscitation from in-hospital cardiac arrest.

Cecelia Ratay, Jonathan Elmer, Clifton W Callaway, Katharyn L Flickinger, Patrick J Coppler, University of Pittsburgh Post-Cardiac Arrest Service

Open access · hybridAbstract read
In one paragraph

Article in Resuscitation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
4.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Cecelia RatayDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: rataycr2@upmc.edu.
Jonathan ElmerDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Clifton W CallawayDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Katharyn L FlickingerDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Patrick J CopplerDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
University of Pittsburgh Post-Cardiac Arrest Service
University of Pittsburgh · US

Funding

PREcision Care In Cardiac ArrEst - ICECAP (PRECICECAP)R01NS119825 · NINDS · STANFORD UNIVERSITY · PI ELMER, JONATHAN, HIRSCH, KAREN G · 2021 to 2025
$7.0M
Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) - Clinical Coordinating Center (CCC)U24NS100659 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILLIAM G BARSAN, Clifton W. Callaway · 2017 to 2026
$6.4M
Optimizing Recovery prediction after Cardiac Arrest (ORCA)R01NS124642 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jonathan Elmer · 2022 to 2026
$3.2M
Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) - PittsburghU24NS100656 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Clifton W. Callaway · 2017 to 2026
$2.4M
Quantitative electroencephalography after cardiac arrestK23NS097629 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ELMER, JONATHAN · 2017 to 2021
$945k
NINDS NIH HHS K23 NS097629NINDS NIH HHS R01 NS119825NINDS NIH HHS R01 NS124642NINDS NIH HHS U24 NS100656NINDS NIH HHS U24 NS100659
6 · The paper itself

Abstract

backgroundFew data characterize the role of brain computed tomography (CT) after resuscitation from in-hospital cardiac arrest (IHCA). We hypothesized that identifying a neurological etiology of arrest or cerebral edema on brain CT are less common after IHCA than after resuscitation from out-of-hospital cardiac arrest (OHCA).

methodsWe included all patients comatose after resuscitation from IHCA or OHCA in this retrospective cohort analysis. We abstracted patient and arrest clinical characteristics, as well as pH and lactate, to estimate systemic illness severity. Brain CT characteristics included quantitative measurement of the grey-to-white ratio (GWR) at the level of the basal ganglia and qualitative assessment of sulcal and cisternal effacement. We compared GWR distribution by stratum (no edema ≥1.30, mild-to-moderate <1.30 and >1.20, severe ≤1.20) and newly identified neurological arrest etiology between IHCA and OHCA groups.

resultsWe included 2,306 subjects, of whom 420 (18.2%) suffered IHCA. Fewer IHCA subjects underwent post-arrest brain CT versus OHCA subjects (149 (35.5%) vs 1,555 (82.4%), p < 0.001). Cerebral edema for IHCA versus OHCA was more often absent (60.1% vs. 47.5%) or mild-to-moderate (34.3% vs. 27.9%) and less often severe (5.6% vs. 24.6%). A neurological etiology of arrest was identified on brain CT in 0.5% of IHCA versus 3.2% of OHCA.

conclusionsAlthough severe edema was less frequent in IHCA relative to OHCA, mild-to-moderate or severe edema occurred in one in three patients after IHCA. Unsuspected neurological etiologies of arrest were rarely discovered by CT scan in IHCA patients.

Indexed as

Brain EdemaCardiopulmonary ResuscitationHeart ArrestOut-of-Hospital Cardiac ArrestTomography, X-Ray ComputedAgedBrainComaFemaleHumansMaleMiddle AgedRetrospective StudiesAnoxic brain injuryBrain CTCardiac arrestCerebral edema

Identifiers

PMID38492716
PMCPMC12862590
OpenAlexW4392859759

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.